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Table 2 Univariate and multivariate analyses of prognostic factors for overall survival among patients with recurrent pancreatic cancer

From: Sarcopenia as a prognostic factor in patients with recurrent pancreatic cancer: a retrospective study

Variables Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Age at time of recurrence (≥ 75 vs. < 75) 0.886 0.521–1.507 0.655    
Sex (male vs. female) 0.875 0.505–1.515 0.633    
BMI at the time of recurrence (< 21.8 kg/m2 vs. ≥ 21.8 kg/m2) 2.249 1.186–4.264 0.013 1.203 0.608–2.380 0.596
Smoking status at the time of recurrence (current or former vs. never) 0.903 0.478–1.707 0.753    
Primary tumor location (head vs. body and tail) 0.876 0.512–1.499 0.630    
Primary tumor size (≥ 28.9 mm vs. < 28.9 mm) 1.396 0.826–2.361 0.213    
Histological grading for primary tumor (G1 vs. other) 0.729 0.435–1.222 0.230    
Lymph node metastasis at initial surgery (present vs. absent) 1.624 0.911–2.895 0.100 1.560 0.819–2.972 0.176
Surgical margin at the initial resection (present vs. absent) 0.940 0.445–1.986 0.871    
Serum CA19-9 level at time of recurrence (≥ 107.95 U/ml vs. < 107.95 U/ml) 0.931 0.548–1.583 0.793    
NLR (≥ 1.69 mm vs. < 1.69 mm) 2.544 1.460–4.434 0.001 2.357 1.314–4.228 0.004
Time to recurrence after pancreatectomy (< 12 months [early] vs. ≥ 12 months [late]) 2.618 1.489–4.604 0.001 2.940 1.551–5.573 0.001
Initial site of recurrence (distant vs. local) 1.227 0.717–2.100 0.456    
Chemotherapy after recurrence (present vs. absent) 0.489 0.266–0.898 0.021 0.348 0.165–0.732 0.005
Sarcopenia at time of recurrence (present vs. absent) 2.846 1.029–7.871 0.044 3.094 1.035–9.248 0.043
  1. HR hazard ratio, CI confidence interval, G1 well-differentiated, BMI body mass index, CA19-9 carbohydrate antigen 19-9, NLR neutrophil-to-lymphocyte ratio