Table 3 Cox regression analysis evaluating the value of surgical margins and perineural invasion as a predictor of time to biochemical recurrence in a subgroup analysis regarding Gleason Score
Variable | Gleason Score < 8 (n = 246) | Gleason Score ≥ 8 (n = 170) | ||||||
|---|---|---|---|---|---|---|---|---|
Univariable | Multivariable1 | Univariable | Multivariable1 | |||||
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Surgical margins | 0.041 | 0.033 | 0.002 | 0.001 | ||||
NSM | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) | ||||
AM | 4.4 (1.5–12.7) | 0.006 | 5.1 (1.7–14.7) | 0.003 | 2.2 (1.0–4.9) | 0.049 | 3.8 (1.6–8.7) | 0.002 |
OM | - | 0.984 | 2.2 (1.2–4.4) | 0.012 | 1.6 (0.8–3.1) | 0.164 | ||
MM | 3.0 (0.7–13.7) | 0.15 | 2.0 (0.4–9.2) | 0.394 | 2.9 (1.6–5.1) | <0.001 | 3.0 (1.6–5.6) | 0.001 |
Perineural invasion | ||||||||
No | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) | ||||
Yes | 1.4 (0.5–3.8) | 0.561 | 1.8 (1.1–2.8) | 0.016 | 1.2 (0.7–1.9) | 0.493 | ||