Skip to main content

Table 3 Cox regression analysis evaluating the value of surgical margins and perineural invasion as a predictor of time to biochemical recurrence in a subgroup analysis regarding Gleason Score

From: Impact of positive surgical margin location and perineural invasion on biochemical recurrence in patients undergoing radical prostatectomy

Variable Gleason Score < 8 (n = 246) Gleason Score ≥ 8 (n = 170)
Univariable Multivariable1 Univariable Multivariable1
HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
Surgical margins   0.041   0.033   0.002   0.001
 NSM 1.0 (Ref.)   1.0 (Ref.)   1.0 (Ref.)   1.0 (Ref.)  
 AM 4.4 (1.5–12.7) 0.006 5.1 (1.7–14.7) 0.003 2.2 (1.0–4.9) 0.049 3.8 (1.6–8.7) 0.002
 OM - 0.984    2.2 (1.2–4.4) 0.012 1.6 (0.8–3.1) 0.164
 MM 3.0 (0.7–13.7) 0.15 2.0 (0.4–9.2) 0.394 2.9 (1.6–5.1) <0.001 3.0 (1.6–5.6) 0.001
Perineural invasion
 No 1.0 (Ref.)   1.0 (Ref.)   1.0 (Ref.)   1.0 (Ref.)  
 Yes 1.4 (0.5–3.8) 0.561    1.8 (1.1–2.8) 0.016 1.2 (0.7–1.9) 0.493
  1. 1Adjusted for BMI, TPSA, and pathological tumor stage