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Table 2 Univariate and multivariate model and hazard ratio calculations for variables associated with biochemical recurrence

From: Impact of positive surgical margin location and perineural invasion on biochemical recurrence in patients undergoing radical prostatectomy

Variables

Univariable cox regression

Multivariable cox regression (backward stepwise)

HR (95% CI)

p value

HR (95% CI)

p value

Age (years)

0.993 (0965–1.023)

0.646

  

BMI (kg/m2)

0.939 (0.875–1.008)

0.081

0.975 (0.906–1.050)

0.508

Volume(ml)

1.005 (0.995–1.015)

0.349

  

TPSA (ng/ml)

1.016 (1.013–1.018)

< 0.001

1.012 (1.009–1.016)

< 0.001

Surgical approach

 ORP

1.000 (Ref.)

0.979

  

 LRP

1.006 (0.665–1.521)

 

Gleason score

 < 8

1.000 (Ref.)

< 0.001

1.000 (Ref.)

< 0.001

 ≥ 8

7.796 (4.702–12.925)

4.629 (2.718–7.883)

pT stage

 

 T2

1.000 (Ref.)

< 0.001

1.000 (Ref.)

< 0.001

 T3

3.239 (2.136–4.911)

2.526 (1.614–3.955)

Surgical margin

 

< 0.001

 

< 0.001

 NSM

1.000 (Ref.)

 

1.000 (Ref.)

 

 AM

2.687 (1.443–5.005)

0.002

4.192 (2.185–8.042)

< 0.001

 OM

3.147 (1.689–5.862)

<0.001

1.501 (0.794–2.838)

0.211

 MM

4.530 (2.702–7.595)

<0.001

2.758 (1.559–4.880)

< 0.001

Perineural invasion

 No

1.000 (Ref.)

< 0.001

 

0.369

 Yes

2.503 (1.669–3.753)

1.219 (0.791–1.877)