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Table 1 Clinical and histological characteristics of patients according to the location of positive surgical margin (PSM)

From: Impact of positive surgical margin location and perineural invasion on biochemical recurrence in patients undergoing radical prostatectomy

Characteristics Total Surgical margin p value
NSM AM OM MM
Patients, no. (%) 416 (100) 284 (100) 43 (100) 37 (100) 52 (100) -
Age, years, median (IQR) 68 (62–72) 67 (62–72) 68 (63–71) 68 (64–71) 68 (61–75) 0.922
BMI, kg/m2, median (IQR) 24.9 (23.5–27.0) 25.0 (23.7–27.1) 24.7 (23.8–27.1) 25.1 (22.9–27.0) 24.0 (22.9–27.0) 0.078
Volume, ml, median (IQR) 24.6 (18.7–34.6) 24.6 (18.7–36.1) 19.5 (16.6–28.1) 25.7 (18.1–36.3) 26.4 (16.4–35.9) 0.167
PSA, ng/ml, median (IQR) 15.8 (8.8–29.8) 13.1 (8.3–25.7) 15.8 (7.3–25.6) 26.0 (13.8–57.0) 22.6 (14.0–55.9) < 0.001
Surgical approach, no. (%)
 ORP 152 (37) 125 (44) 8 (19) 12 (32) 7 (13) < 0.001
 LRP 264 (63) 159 (56) 35 (81) 25 (68) 45 (87)
Gleason score, no. (%)      
 < 8 246 (59) 193 (68) 25 (58) 14 (38) 14 (27) < 0.001
 ≥ 8 170 (41) 91 (32) 18 (42) 23 (62) 38 (73)
pTNM, no. (%)
 T2 270 (65) 187 (66) 34 (79) 15 (41) 34 (65) 0.004
 T3 146 (35) 97 (34) 9 (21) 22 (59) 18 (35)
Perineural invasion, no. (%)
 No 289 (69) 213 (75) 30 (70) 22 (59) 24 (46) < 0.001
 Yes 127 (31) 71 (25) 13 (30) 15 (41) 28 (54)
BCR
 No 322 (77) 238 (84) 30 (70) 24 (65) 30 (58) < 0.001
 Yes 94 (23) 46 (16) 13 (30) 13 (35) 22 (42)
Follow-up time, median (IQR) 27 (20–47) 32 (23–44) 23 (19–29) 25 (17–31) 19 (16–26) < 0.001
  1. NSM negative surgical margins, AM a solitary positive apical margin, OM a solitary nonapical positive margin, MM multiple positive surgical margins, PSA prostate-specific antigen, BCR biochemical recurrence