Skip to main content

Table 5 Summary of different phenotypes between Lynch syndrome (LS) and familial colorectal cancer type X (FCCTX) in the literature

From: Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria

  Age at diagnosis of CRC Tumor location Rate of meta-chronous CRC Rate of extra-colonic 2nd tumor
LS vs. FCCTX LS vs. FCCTX LS vs. FCCTX LS vs. FCCTX
Valle [13] Mean
41 vs. 53 years
Right colon 26.3% vs. 7.7% No data
p < 0.001 70.6% vs. 20.8% NS
  Rectum  
11.8% vs. 41.7%  
Mueller-Koch [14] Median
41 vs. 55 years
Right colon 11.3% vs. 1.4% 16% vs. 1.4%
p < 0.001 68% vs. 14% p = 0.017 p < 0.001
  p < 0.010   
Xavier L [15] 64.8 vs. 67.8 years Right colon No data 5.1% vs. 3.3%
p = 0.603 44.4% vs. 13.3% NS
  p = 0.15  
Shiovitz [6] Mean
53.3 vs. 50.5 years
Right colon No data No data
   61% vs. 31%
  Rectum
15% vs. 34%
Yamaguchi [16] Median
48 vs. 45 years
Right colon No data 37.6% vs. 4%
p = 0.39 56% vs. 62% p = 0.001
This study Mean
54.3 vs. 48.6 years
Right colon 8.3% vs. 1.8% 16.7% vs. 1.8%
p = 0.007 62% vs. 27% p = 0.177 p = 0.005
  Rectum   
12% vs. 42%
p < 0.001
  1. NS not significant