Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria

Table 5 Summary of different phenotypes between Lynch syndrome (LS) and familial colorectal cancer type X (FCCTX) in the literature

	Age at diagnosis of CRC	Tumor location	Rate of meta-chronous CRC	Rate of extra-colonic 2^nd tumor
	LS vs. FCCTX	LS vs. FCCTX	LS vs. FCCTX	LS vs. FCCTX
Valle [13]	Mean 41 vs. 53 years	Right colon	26.3% vs. 7.7%	No data
	p < 0.001	70.6% vs. 20.8%	NS
		Rectum
		11.8% vs. 41.7%
Mueller-Koch [14]	Median 41 vs. 55 years	Right colon	11.3% vs. 1.4%	16% vs. 1.4%
	p < 0.001	68% vs. 14%	p = 0.017	p < 0.001
		p < 0.010
Xavier L [15]	64.8 vs. 67.8 years	Right colon	No data	5.1% vs. 3.3%
	p = 0.603	44.4% vs. 13.3%		NS
		p = 0.15
Shiovitz [6]	Mean 53.3 vs. 50.5 years	Right colon	No data	No data
		61% vs. 31%
		Rectum
		15% vs. 34%
Yamaguchi [16]	Median 48 vs. 45 years	Right colon	No data	37.6% vs. 4%
Yamaguchi [16]	p = 0.39	56% vs. 62%	No data	p = 0.001
This study	Mean 54.3 vs. 48.6 years	Right colon	8.3% vs. 1.8%	16.7% vs. 1.8%
	p = 0.007	62% vs. 27%	p = 0.177	p = 0.005
		Rectum
		12% vs. 42%
		p < 0.001

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