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Table 4 Univariate and multivariate analyses of overall survival (OS) related to clinical variables

From: Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria

Characteristics N OS (%) p value Multiple Cox
1 years 3 years 5 years HR 95% C.I. p
NHPCC      < 0.001    
 pMMR 55 92.59 74.07 64.51   1   
 dMMR 120 94.95 88.97 87.25   0.48 (0.239~0.966) 0.040
Sex      0.548    
 F 92 94.57 85.78 81.38     
 M 83 93.81 82.55 78.7     
Operation type      0.006    
 Hemicolectomy 124 91.8 78.45 73.4   1   
 Sub/total colectomy 51 100 98.04 96.04   0.57 (0.242~1.348) 0.201
Tumor location      < 0.001    
 Right colon 89 94.25 88.36 86.01   1   
 Left colon 49 97.96 91.84 89.8   1.25 (0.568~2.731) 0.584
 Rectum 37 89.19 64.86 53.51   1.42 (0.629~3.217) 0.397
Tumor histology      0.281    
 Adenocarcinoma 146 95.17 83.98 79.04     
 Mucinous/signet ring 25 91.67 87.5 87.5     
 Unclassified 4 75 75 75     
Tumor differentiation      0.276    
 Well 30 100 100 92.98     
 Moderate 109 93.57 81.53 76.89     
 Poor 33 90.63 80.92 80.92     
 Unclassified 3 100 66.67 66.67     
TNM_T stage      0.255    
 1 13 100 100 83.92     
 2 14 92.86 92.86 92.86     
 3 85 98.81 84.17 81.69     
 4 61 88.52 80.33 75.41     
TNM_N stage      < 0.001    
 0 112 97.3 92.79 89.16   1   
 1 37 97.3 88.71 82.78   1.18 (0.504~2.757) 0.704
 2 20 85 50 45   4.70 (2.063~10.713) < 0.001
 3 4 50   7.41 (1.563~35.110) 0.012
TNM_M stage      < 0.001    
 No 161 97.5 88.64 85.44   1   
 Yes 14 53.85 30.77   5.24 (1.876~14.649) 0.002