Table 1 Clinicopathological characteristics of HNPCC patients, and comparisons of between dMMR and pMMR patients
| Characteristics |
All patients (N = 175) | HNPCC | p value | |
|---|---|---|---|---|
| pMMR (n = 55) | dMMR (n = 120) | |||
| Age | ||||
| Mean (SD) | 50.41 (12.98) | 54.31 (13.66) | 48.62 (12.30) | 0.007 |
| Median (range) | 49 (26~88) | 51 (29~88) | 48 (26~78) | 0.017 |
| Sex | 0.054 | |||
| F | 92 (52.57) | 23 (41.82) | 69 (57.50) | |
| M | 83 (47.43) | 32 (58.18) | 51 (42.50) | |
| OP type | 0.004 | |||
| Segmental colectomy | 124 (70.86) | 47 (85.45) | 77 (64.17) | |
| Extended colectomy | 51 (29.14) | 8 (14.55) | 43 (35.83) | |
| Tumor location | < 0.001 | |||
| Right colon | 89 (50.86) | 15 (27.27) | 74 (61.67) | |
| Left colon | 49 (28.00) | 17 (30.91) | 32 (26.67) | |
| Rectum | 37 (21.14) | 23 (41.82) | 14 (11.67) | |
| Tumor histology | 0.402 | |||
| Adenocarcinoma | 146 (83.43) | 49 (89.09) | 97 (80.83) | |
| Mucinous/signet ring | 25 (14.29) | 5 (9.09) | 20 (16.67) | |
| Unclassified | 4 (2.29) | 1 (1.82) | 3 (2.50) | |
| Tumor differentiation | 0.065 | |||
| Well | 30 (17.14) | 12 (21.82) | 18 (15.00) | |
| Moderate | 109 (62.29) | 38 (69.09) | 71 (59.17) | |
| Poor | 33 (18.86) | 5 (9.09) | 28 (23.33) | |
| Unclassified | 3 (1.71) | 0 (0.00) | 3 (2.50) | |
| TNM_T stage | 0.421 | |||
| 1 | 13 (7.51) | 5 (9.43) | 8 (6.67) | |
| 2 | 14 (8.09) | 3 (5.66) | 11 (9.17) | |
| 3 | 85 (49.13) | 30 (56.60) | 55 (45.83) | |
| 4 | 61 (35.26) | 15 (28.30) | 46 (38.33) | |
| TNM_N stage | 0.049 | |||
| 0 | 112 (64.74) | 27 (50.94) | 85 (70.83) | |
| 1 | 37 (21.39) | 15 (28.30) | 22 (18.33) | |
| 2 | 20 (11.56) | 10 (18.87) | 10 (8.33) | |
| 3 | 4 (2.31) | 1 (1.89) | 3 (2.50) | |
| TNM_M stage | > 0.99 | |||
| 0 | 161 (92.00) | 51 (92.73) | 110 (91.67) | |
| 1 | 14 (8.00) | 4 (7.27) | 10 (8.33) | |
| Disease recurrence | < 0.001 | |||
| No | 133 (76.00) | 33 (64.70) | 100 (90.90) | |
| Yes | 42 (24.00) | 18 (35.30) | 10 (9.10) | |
| Extra-colonic tumor | 0.005 | |||
| Absent | 154 (88.00) | 54 (98.18) | 100 (83.33) | |
| Present | 21 (12.00) | 1 (1.82) | 20 (16.67) | |
| Metachronous colon tumor | 0.177 | |||
| Absent | 146 (83.43) | 54 (98.18) | 110 (91.67) | |
| Present | 29 (16.57) | 1 (1.82) | 10 (8.33) | |
| Death | 0.003 | |||
| Alive | 128 (73.14) | 32 (58.18) | 96 (80.00) | |
| Deceased | 47 (26.86) | 23 (41.82) | 24 (20.00) | |
| Follow-up month | 97.08 (0.00~239.93) | 69.78 (0.00~137.95) | 117.47 (0.00~239.93) | 0.014 |