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Table 1 Clinicopathological characteristics of HNPCC patients, and comparisons of between dMMR and pMMR patients

From: Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria

Characteristics All patients
(N = 175)
HNPCC p value
pMMR (n = 55) dMMR (n = 120)
Age     
 Mean (SD) 50.41 (12.98) 54.31 (13.66) 48.62 (12.30) 0.007
 Median (range) 49 (26~88) 51 (29~88) 48 (26~78) 0.017
Sex     0.054
 F 92 (52.57) 23 (41.82) 69 (57.50)  
 M 83 (47.43) 32 (58.18) 51 (42.50)  
OP type     0.004
 Segmental colectomy 124 (70.86) 47 (85.45) 77 (64.17)  
 Extended colectomy 51 (29.14) 8 (14.55) 43 (35.83)  
Tumor location     < 0.001
 Right colon 89 (50.86) 15 (27.27) 74 (61.67)  
 Left colon 49 (28.00) 17 (30.91) 32 (26.67)  
 Rectum 37 (21.14) 23 (41.82) 14 (11.67)  
Tumor histology     0.402
 Adenocarcinoma 146 (83.43) 49 (89.09) 97 (80.83)  
 Mucinous/signet ring 25 (14.29) 5 (9.09) 20 (16.67)  
 Unclassified 4 (2.29) 1 (1.82) 3 (2.50)  
Tumor differentiation     0.065
 Well 30 (17.14) 12 (21.82) 18 (15.00)  
 Moderate 109 (62.29) 38 (69.09) 71 (59.17)  
 Poor 33 (18.86) 5 (9.09) 28 (23.33)  
 Unclassified 3 (1.71) 0 (0.00) 3 (2.50)  
TNM_T stage     0.421
 1 13 (7.51) 5 (9.43) 8 (6.67)  
 2 14 (8.09) 3 (5.66) 11 (9.17)  
 3 85 (49.13) 30 (56.60) 55 (45.83)  
 4 61 (35.26) 15 (28.30) 46 (38.33)  
TNM_N stage     0.049
 0 112 (64.74) 27 (50.94) 85 (70.83)  
 1 37 (21.39) 15 (28.30) 22 (18.33)  
 2 20 (11.56) 10 (18.87) 10 (8.33)  
 3 4 (2.31) 1 (1.89) 3 (2.50)  
TNM_M stage     > 0.99
 0 161 (92.00) 51 (92.73) 110 (91.67)  
 1 14 (8.00) 4 (7.27) 10 (8.33)  
Disease recurrence     < 0.001
 No 133 (76.00) 33 (64.70) 100 (90.90)  
 Yes 42 (24.00) 18 (35.30) 10 (9.10)  
Extra-colonic tumor     0.005
 Absent 154 (88.00) 54 (98.18) 100 (83.33)  
 Present 21 (12.00) 1 (1.82) 20 (16.67)  
Metachronous colon tumor    0.177
 Absent 146 (83.43) 54 (98.18) 110 (91.67)  
 Present 29 (16.57) 1 (1.82) 10 (8.33)  
Death     0.003
 Alive 128 (73.14) 32 (58.18) 96 (80.00)  
 Deceased 47 (26.86) 23 (41.82) 24 (20.00)  
Follow-up month 97.08 (0.00~239.93) 69.78 (0.00~137.95) 117.47 (0.00~239.93) 0.014