Table 1 Clinicopathological characteristics of HNPCC patients, and comparisons of between dMMR and pMMR patients

Age

 Mean (SD)

50.41 (12.98)

54.31 (13.66)

48.62 (12.30)

0.007

 Median (range)

49 (26~88)

51 (29~88)

48 (26~78)

0.017

Sex

0.054

 F

92 (52.57)

23 (41.82)

69 (57.50)

 M

83 (47.43)

32 (58.18)

51 (42.50)

OP type

0.004

 Segmental colectomy

124 (70.86)

47 (85.45)

77 (64.17)

 Extended colectomy

51 (29.14)

8 (14.55)

43 (35.83)

Tumor location

< 0.001

 Right colon

89 (50.86)

15 (27.27)

74 (61.67)

 Left colon

49 (28.00)

17 (30.91)

32 (26.67)

 Rectum

37 (21.14)

23 (41.82)

14 (11.67)

Tumor histology

0.402

 Adenocarcinoma

146 (83.43)

49 (89.09)

97 (80.83)

 Mucinous/signet ring

25 (14.29)

5 (9.09)

20 (16.67)

 Unclassified

4 (2.29)

1 (1.82)

3 (2.50)

Tumor differentiation

0.065

 Well

30 (17.14)

12 (21.82)

18 (15.00)

 Moderate

109 (62.29)

38 (69.09)

71 (59.17)

 Poor

33 (18.86)

5 (9.09)

28 (23.33)

 Unclassified

3 (1.71)

0 (0.00)

3 (2.50)

TNM_T stage

0.421

 1

13 (7.51)

5 (9.43)

8 (6.67)

 2

14 (8.09)

3 (5.66)

11 (9.17)

 3

85 (49.13)

30 (56.60)

55 (45.83)

 4

61 (35.26)

15 (28.30)

46 (38.33)

TNM_N stage

0.049

 0

112 (64.74)

27 (50.94)

85 (70.83)

 1

37 (21.39)

15 (28.30)

22 (18.33)

 2

20 (11.56)

10 (18.87)

10 (8.33)

 3

4 (2.31)

1 (1.89)

3 (2.50)

TNM_M stage

> 0.99

 0

161 (92.00)

51 (92.73)

110 (91.67)

 1

14 (8.00)

4 (7.27)

10 (8.33)

Disease recurrence

< 0.001

 No

133 (76.00)

33 (64.70)

100 (90.90)

 Yes

42 (24.00)

18 (35.30)

10 (9.10)

Extra-colonic tumor

0.005

 Absent

154 (88.00)

54 (98.18)

100 (83.33)

 Present

21 (12.00)

1 (1.82)

20 (16.67)

0.177

 Absent

146 (83.43)

54 (98.18)

110 (91.67)

 Present

29 (16.57)

1 (1.82)

10 (8.33)

Death

0.003

 Alive

128 (73.14)

32 (58.18)

96 (80.00)

 Deceased

47 (26.86)

23 (41.82)

24 (20.00)

Follow-up month

97.08 (0.00~239.93)

69.78 (0.00~137.95)

117.47 (0.00~239.93)

0.014