Table 3 Enrichment of functions and signaling pathways with BSG-related gene in thyroid cancer

GO_BP

Extracellular matrix organization

52

4

5.9E− 17

GO_BP

Cell adhesion

81

6.2

1.4E− 14

GO_BP

Inflammatory response

62

4.8

6E− 10

GO_BP

Signal transduction

128

9.8

1.5E− 07

GO_BP

Collagen catabolic process

19

1.5

2.2E− 07

GO_BP

Endothelial cell migration

12

0.9

1.9E− 06

GO_BP

Positive regulation of synapse assembly

17

1.3

3.5E− 06

GO_BP

Cellular response to tumor necrosis factor

23

1.8

5.8E− 06

GO_BP

Response to drug

44

3.4

6.9E− 06

GO_BP

Leukocyte migration

24

1.8

0.00001

GO_BP

Positive regulation of apoptotic process

43

3.3

0.000011

GO_BP

BMP signaling pathway

18

1.4

0.000014

GO_BP

Vasculogenesis

15

1.2

0.000021

GO_BP

Skeletal system development

25

1.9

0.000024

GO_BP

Angiogenesis

34

2.6

0.000031

GO_BP

Response to mechanical stimulus

15

1.2

0.00004

GO_BP

Response to axon injury

10

0.8

0.000055

GO_BP

Positive regulation of gene expression

37

2.8

0.00007

GO_BP

SMAD protein signal transduction

15

1.2

0.000072

GO_BP

Cell chemotaxis

15

1.2

0.00012

GO_CC

Extracellular space

199

15.3

1.9E− 26

GO_CC

Proteinaceous extracellular matrix

70

5.4

1.3E− 22

GO_CC

Extracellular region

208

16

2.4E− 20

GO_CC

Extracellular exosome

311

23.9

6E− 20

GO_CC

Extracellular matrix

62

4.8

4.5E− 15

GO_CC

Cell surface

80

6.2

1E− 10

GO_CC

Collagen trimer

26

2

1.5E− 09

GO_CC

Integral component of plasma membrane

151

11.6

2.5E− 08

GO_CC

Plasma membrane

361

27.8

4.4E− 08

GO_CC

Basement membrane

20

1.5

1.1E− 06

GO_CC

Receptor complex

24

1.8

0.000015

GO_CC

Perinuclear region of cytoplasm

71

5.5

0.000023

GO_CC

Endoplasmic reticulum lumen

29

2.2

0.00011

GO_CC

Dendritic spine

19

1.5

0.00013

GO_CC

Z disk

21

1.6

0.00014

GO_CC

Integral component of membrane

409

31.5

0.0002

GO_CC

Anchored component of membrane

20

1.5

0.00022

GO_CC

Focal adhesion

46

3.5

0.00041

GO_CC

Endoplasmic reticulum

82

6.3

0.00064

GO_CC

Cell

17

1.3

0.0012

GO_MF

Calcium ion binding

99

7.6

1.2E− 11

GO_MF

Heparin binding

37

2.8

1E− 10

GO_MF

Extracellular matrix structural constituent

20

1.5

5.3E− 08

GO_MF

Identical protein binding

89

6.8

2.1E− 07

GO_MF

Integrin binding

23

1.8

1.6E− 06

GO_MF

Protein homodimerization activity

79

6.1

0.000035

GO_MF

Glycoprotein binding

15

1.2

0.000089

GO_MF

SMAD binding

12

0.9

0.000098

GO_MF

Extracellular matrix binding

9

0.7

0.00022

GO_MF

Transforming growth factor beta binding

7

0.5

0.00042

GO_MF

Calcium-dependent phospholipid binding

13

1

0.00042

GO_MF

Collagen binding

13

1

0.00058

GO_MF

Aldehyde dehydrogenase (NAD) activity

7

0.5

0.00061

GO_MF

Receptor activity

29

2.2

0.00073

GO_MF

Low-density lipoprotein receptor activity

6

0.5

0.0011

GO_MF

Chemokine activity

11

0.8

0.0014

GO_MF

Actin filament binding

20

1.5

0.0014

GO_MF

Calcium-dependent protein binding

12

0.9

0.0015

GO_MF

Structural constituent of muscle

10

0.8

0.0017

GO_MF

Protein binding

642

49.4

0.0018

KEGG_PATHWAY

ECM-receptor interaction

25

1.9

1.3E− 08

KEGG_PATHWAY

Complement and coagulation cascades

20

1.5

4.5E− 07

KEGG_PATHWAY

Staphylococcus aureus infection

17

1.3

1.2E− 06

KEGG_PATHWAY

p53 signaling pathway

18

1.4

6.2E− 06

KEGG_PATHWAY

Protein digestion and absorption

20

1.5

0.000022

KEGG_PATHWAY

Malaria

14

1.1

0.000046

KEGG_PATHWAY

Amoebiasis

21

1.6

0.0001

KEGG_PATHWAY

Transcriptional misregulation in cancer

28

2.2

0.00012

KEGG_PATHWAY

Phagosome

26

2

0.00013

KEGG_PATHWAY

Focal adhesion

32

2.5

0.00015

KEGG_PATHWAY

Pathways in cancer

49

3.8

0.0005

KEGG_PATHWAY

Pertussis

15

1.2

0.0012

KEGG_PATHWAY

Cytokine-cytokine receptor interaction

33

2.5

0.0013

KEGG_PATHWAY

Thyroid hormone synthesis

14

1.1

0.0019

KEGG_PATHWAY

Leukocyte transendothelial migration

19

1.5

0.0023

KEGG_PATHWAY

Cell adhesion molecules (CAMs)

21

1.6

0.0047

KEGG_PATHWAY

Mineral absorption

10

0.8

0.0048

KEGG_PATHWAY

Leishmaniasis

13

1

0.0063

KEGG_PATHWAY

PI3K-Akt signaling pathway

40

3.1

0.0065

KEGG_PATHWAY

TGF-beta signaling pathway

14

1.1

0.0097