Table 5 Multivariable Cox regression analyses for metastasis colorectal cancer patients in PTR and non-PTR groups
Variables | Overall survival | Cancer-specific survival | ||||||
|---|---|---|---|---|---|---|---|---|
Non-PTR | PTR | Non-PTR | PTR | |||||
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Age | ||||||||
< 60 | Reference | Reference | Reference | Reference | ||||
≥ 60 | 1.363 (1.224–1.517) | < 0.001 | 1.265 (1.175–1.361) | < 0.001 | 1.342 (1.203–1.498) | < 0.001 | 1.240 (1.150–1.337) | < 0.001 |
Gender | ||||||||
Male | – | Reference | – | Reference | ||||
Female | – | 1.082 (1.009–1.160) | 0.026 | – | 1.081 (1.006–1.161) | 0.033 | ||
Race | ||||||||
Black | Reference | – | Reference | Reference | ||||
White | 1.192 (1.037–1.371) | 0.014 | – | 1.177 (1.019–1.359) | 0.027 | 1.049 (0.951–1.157) | 0.338 | |
Other | 0.837 (0.699–1.004) | 0.055 | – | 0.860 (0.715–1.033) | 0.107 | 0.930 (0.819–1.057) | 0.270 | |
Grade | ||||||||
I and II | Reference | Reference | Reference | Reference | ||||
III and IV | 1.632 (1.439–1.851) | < 0.001 | 1.601 (1.483–1.729) | < 0.001 | 1.638 (1.440–1.864) | < 0.001 | 1.620 (1.497–1.752) | < 0.001 |
Primary site | ||||||||
Proximal colon | Reference | Reference | Reference | Reference | ||||
Distal colon | 0.785 (0.670–0.919) | 0.003 | 0.766 (0.704–0.833) | < 0.001 | 0.769 (0.654–0.904) | 0.001 | 0.748 (0.686–0.816) | < 0.001 |
Rectum | 0.628 (0.547–0.720) | < 0.001 | 0.830 (0.746–0.922) | 0.001 | 0.614 (0.534–0.707) | < 0.001 | 0.809 (0.725–0.903) | < 0.001 |
Other | 1.156 (0.769–1.739) | 0.486 | 1.099 (0.882–1.370) | 0.399 | 1.147 (0.756–1.740) | 0.519 | 1.131 (0.904–1.413) | 0.281 |
Histology type | ||||||||
AC | Reference | Reference | Reference | Reference | ||||
MAC | 1.091 (0.825–1.443) | 0.539 | 1.235 (1.100–1.387) | < 0.001 | 1.055 (0.789–1.411) | 0.717 | 1.263 (1.122–1.422) | < 0.001 |
SRCC | 1.133 (0.805–1.596) | 0.474 | 1.720 (1.335–2.215) | < 0.001 | 1.163 (0.821–1.647) | 0.395 | 1.748 (1.348–2.266) | < 0.001 |
CEA | ||||||||
Normal | Reference | Reference | Reference | Reference | ||||
Abnormal | 1.357 (1.156–1.592) | < 0.001 | 1.554 (1.419–1.703) | < 0.001 | 1.365 (1.158–1.610) | <0.001 | 1.533 (1.396–1.683) | < 0.001 |
Radiotherapy | ||||||||
No | Reference | Reference | Reference | Reference | ||||
Yes | 0.983 (0.856–1.129) | 0.807 | 0.819 (0.710–0.945) | 0.006 | 0.952 (0.825–1.099) | 0.501 | 0.838 (0.723–0.970) | 0.018 |
Chemotherapy | ||||||||
No | Reference | Reference | Reference | Reference | ||||
Yes | 0.304 (0.268–0.344) | < 0.001 | 0.382 (0.354–0.412) | < 0.001 | 0.305 (0.268–0.347) | < 0.001 | 0.389 (0.359–0.421) | < 0.001 |
T stage | ||||||||
T1 and T2 | – | Reference | – | Reference | ||||
T3 and T4 | – | 1.152 (0.960–1.382) | 0.128 | – | 1.149 (0.951–1.388) | 0.150 | ||
N stage | ||||||||
N0 | Reference | Reference | Reference | Reference | ||||
N1 | 1.045 (0.935–1.167) | 0.439 | 1.170 (1.051–1.301) | 0.004 | 1.044 (0.932–1.170) | 0.455 | 1.203 (1.076–1.345) | 0.001 |
N2 | 0.934 (0.759–1.150) | 0.521 | 1.482 (1.336–1.644) | < 0.001 | 0.922 (0.743–1.143) | 0.457 | 1.551 (1.393–1.728) | < 0.001 |
Bone metastasis | ||||||||
No | Reference | Reference | Reference | Reference | ||||
Yes | 1.751 (1.454–2.108) | < 0.001 | 1.653 (1.379–1.980) | < 0.001 | 1.722 (1.421–2.088) | < 0.001 | 1.668 (1.386–2.008) | < 0.001 |
Liver metastasis | ||||||||
No | – | Reference | – | Reference | ||||
Yes | – | 1.380 (1.269–1.501) | < 0.001 | – | 1.408 (1.290–1.535) | < 0.001 | ||
Lung metastasis | ||||||||
No | – | Reference | – | Reference | ||||
Yes | – | 1.366 (1.251–1.492) | < 0.001 | – | 1.375 (1.255–1.506) | < 0.001 | ||
Brain metastasis | ||||||||
No | Reference | Reference | Reference | Reference | ||||
Yes | 1.420 (0.959–2.101) | 0.080 | 1.483 (0.983–2.236) | 0.060 | 1.483 (0.995–2.212) | 0.053 | 1.462 (0.952–2.246) | 0.083 |