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Table 4 Univariate Cox regression analyses for metastasis colorectal cancer patients in PTR and non-PTR groups

From: Individualized prediction of survival benefit from primary tumor resection for patients with unresectable metastatic colorectal cancer

Variables

Overall survival

Cancer-specific survival

Non-PTR

 

PTR

Non-PTR

 

PTR

HR (95% CI)

 

p value

 

HR (95% CI)

 

p value

HR (95% CI)

 

p value

 

HR (95% CI)

 

p value

Age

              

 < 60

Reference

   

Reference

  

Reference

   

Reference

  

 ≥ 60

1.519 (1.370–1.684)

 

< 0.001

 

1.529 (1.423–1.641)

 

< 0.001

1.502 (1.350–1.670)

 

< 0.001

 

1.495 (1.390–1.608)

 

< 0.001

Gender

              

 Male

Reference

   

Reference

  

Reference

   

Reference

  

 Female

1.033 (0.931–1.147)

 

0.538

 

1.108 (1.034–1.187)

 

0.003

1.037 (0.931–1.154)

 

0.510

 

1.111 (1.035–1.192)

 

0.004

Race

              

 Black

Reference

   

Reference

  

Reference

   

Reference

  

 White

1.237 (1.078–1.420)

 

0.002

 

1.027 (0.934–1.129)

 

0.583

1.223 (1.061–1.410)

 

0.005

 

1.035 (0.939–1.140)

 

0.490

 Other

0.868 (0.726–1.038)

 

0.120

 

0.909 (0.805–1.027)

 

0.124

0.887 (0.740–1.064)

 

0.198

 

0.880 (0.775–1.000)

 

0.049

Grade

              

 I and II

Reference

   

Reference

  

Reference

   

Reference

  

 III and IV

1.613 (1.434–1.813)

 

< 0.001

 

1.710 (1.589–1.840)

 

< 0.001

1.623 (1.439–1.831)

 

< 0.001

 

1.742 (1.616–1.878)

 

< 0.001

Primary site

              

 Proximal colon

Reference

   

Reference

  

Reference

   

Reference

  

 Distal colon

0.705 (0.605–0.822)

 

< 0.001

 

0.653 (0.602–0.708)

 

< 0.001

0.694 (0.594–0.812)

 

< 0.001

 

0.636 (0.585–0.692)

 

< 0.001

 Rectum

0.585 (0.518–0.662)

 

< 0.001

 

0.591 (0.538–0.650)

 

< 0.001

0.569 (0.502–0.645)

 

< 0.001

 

0.577 (0.523–0.636)

 

< 0.001

 Other

1.410 (0.941–2.114)

 

0.096

 

1.274 (1.023–1.586)

 

0.030

1.408 (0.932–2.128)

 

0.104

 

1.303 (1.044–1.627)

 

0.019

Histology type

              

 AC

Reference

   

Reference

  

Reference

   

Reference

  

 MAC

1.339 (1.018–1.762)

 

0.037

 

1.308 (1.167–1.465)

 

< 0.001

1.308 (0.983–1.740)

 

0.065

 

1.342 (1.195–1.507)

 

< 0.001

 SRCC

1.768 (1.275–2.452)

 

0.001

 

2.124 (1.666–2.707)

 

< 0.001

1.820 (1.307–2.536)

 

< 0.001

 

2.160 (1.685–2.769)

 

< 0.001

CEA

              

 Normal

Reference

   

Reference

  

Reference

   

Reference

  

 Abnormal

1.345 (1.149–1.575)

 

< 0.001

 

1.563 (1.429–1.708)

 

< 0.001

1.356 (1.152–1.595)

 

< 0.001

 

1.547 (1.412–1.695)

 

< 0.001

Radiotherapy

              

 No

Reference

   

Reference

  

Reference

   

Reference

  

 Yes

0.814 (0.722–0.918)

 

0.001

 

0.590 (0.520–0.670)

 

< 0.001

0.785 (0.693–0.889)

 

< 0.001

 

0.596 (0.524–0.678)

 

< 0.001

Chemotherapy

              

 No

Reference

   

Reference

  

Reference

   

Reference

  

 Yes

0.317 (0.281–0.357)

 

< 0.001

 

0.359 (0.334–0.387)

 

< 0.001

0.319 (0.282–0.360)

 

< 0.001

 

0.368 (0.341–0.397)

 

< 0.001

T stage

              

 T1 and T2

Reference

   

Reference

  

Reference

   

Reference

  

 T3 and T4

0.949 (0.856–1.052)

 

0.317

 

1.438 (1.204–1.719)

 

< 0.001

0.928 (0.835–1.031)

 

0.165

 

1.466 (1.219–1.764)

 

< 0.001

N stage

              

 N0

Reference

   

Reference

  

Reference

   

Reference

  

 N1

0.899 (0.809–1.000)

 

0.050

 

1.192 (1.073–1.325)

 

0.001

0.896 (0.804–1.000)

 

0.049

 

1.233 (1.104–1.375)

 

< 0.001

 N2

0.749 (0.610–0.919)

 

0.006

 

1.615 (1.461–1.786)

 

< 0.001

0.735 (0.595–0.908)

 

0.004

 

1.698 (1.529–1.885)

 

< 0.001

Bone metastasis

              

 No

Reference

   

Reference

  

Reference

   

Reference

  

 Yes

1.736 (1.453–2.073)

 

< 0.001

 

1.745 (1.460–2.085)

 

< 0.001

1.698 (1.412–2.042)

 

< 0.001

 

1.762 (1.468–2.115)

 

< 0.001

Liver metastasis

              

 No

Reference

   

Reference

  

Reference

   

Reference

  

 Yes

1.029 (0.910–1.162)

 

0.650

 

1.164 (1.076–1.260)

 

< 0.001

1.075 (0.947–1.220)

 

0.266

 

1.181 (1.089–1.281)

 

< 0.001

Lung metastasis

              

 No

Reference

   

Reference

  

Reference

   

Reference

  

 Yes

1.073 (0.965–1.193)

 

0.196

 

1.211 (1.111–1.319)

 

< 0.001

1.086 (0.974–1.211)

 

0.139

 

1.206 (1.104–1.317)

 

< 0.001

Brain metastasis

              

 No

Reference

   

Reference

  

Reference

   

Reference

  

 Yes

2.027 (1.393–2.950)

 

< 0.001

 

2.021 (1.352–3.020)

 

0.001

2.072 (1.414–3.037)

 

< 0.001

 

1.967 (1.293–2.993)

 

0.002

  1. CI confidence interval, AC adenocarcinoma, MAC mucinous adenocarcinoma, SRCC signet ring cell carcinoma, PTR primary tumor resection
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World Journal of Surgical Oncology

ISSN: 1477-7819

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