Variables | OS | p value* | CSS | p value* |
---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Total | 0.458 (0.422–0.497) | < 0.001 | 0.452 (0.415–0.492) | < 0.001 |
Age | ||||
< 60 | 0.477 (0.421–0.542) | < 0.001 | 0.477 (0.419–0.542) | < 0.001 |
≥ 60 | 0.449 (0.402–0.500) | < 0.001 | 0.438 (0.392–0.491) | < 0.001 |
Gender | ||||
Male | 0.453 (0.408–0.504) | < 0.001 | 0.444 (0.398–0.495) | < 0.001 |
Female | 0.464 (0.407–0.529) | < 0.001 | 0.463 (0.404–0.530) | < 0.001 |
Race | ||||
Black | 0.459 (0.417–0.505) | < 0.001 | 0.453 (0.411–0.499) | < 0.001 |
White | 0.419 (0.340–0.516) | < 0.001 | 0.424 (0.341–0.526) | < 0.001 |
Other | 0.510 (0.385–0.675) | < 0.001 | 0.476 (0.356–0.635) | < 0.001 |
Grade | ||||
I and II | 0.449 (0.408–0.494) | < 0.001 | 0.443 (0.401–0.489) | < 0.001 |
III and IV | 0.477 (0.404–0.562) | < 0.001 | 0.473 (0.399–0.561) | < 0.001 |
Primary site | ||||
Proximal colon | 0.395 (0.341–0.458) | < 0.001 | 0.389 (0.335–0.453) | < 0.001 |
Distal colon | 0.359 (0.302–0.426) | < 0.001 | 0.345 (0.289–0.412) | < 0.001 |
Rectum | 0.563 (0.499–0.637) | < 0.001 | 0.558 (0.492–0.634) | < 0.001 |
Other | 0.341 (0.186–0.627) | 0.001 | 0.358 (0.193–0.666) | 0.001 |
Histology type | ||||
AC | 0.455 (0.418–0.496) | < 0.001 | 0.448 (0.410–0.489) | < 0.001 |
MAC | 0.386 (0.262–0.569) | < 0.001 | 0.396 (0.265–0.591) | < 0.001 |
SRCC | 0.396 (0.204–0.769) | 0.006 | 0.384 (0.195–0.758) | 0.006 |
CEA | ||||
Normal | 0.336 (0.272–0.415) | < 0.001 | 0.320 (0.258–0.398) | < 0.001 |
Abnormal | 0.484 (0.442–0.529) | < 0.001 | 0.481 (0.439–0.528) | < 0.001 |
Radiotherapy | ||||
No | 0.464 (0.423–0.509) | < 0.001 | 0.453 (0.412–0.498) | < 0.001 |
Yes | 0.420 (0.348–0.507) | < 0.001 | 0.435 (0.358–0.529) | < 0.001 |
Chemotherapy | ||||
No | 0.471 (0.401–0.554) | < 0.001 | 0.454 (0.384–0.537) | < 0.001 |
Yes | 0.469 (0.427–0.516) | < 0.001 | 0.466 (0.422–0.514) | < 0.001 |
T stage | ||||
T1 and T2 | 0.436 (0.351–0.541) | < 0.001 | 0.429 (0.343–0.536) | < 0.001 |
T3 and T4 | 0.463 (0.422–0.507) | < 0.001 | 0.457 (0.416–0.502) | < 0.001 |
N stage | ||||
N0 | 0.394 (0.342–0.455) | < 0.001 | 0.383 (0.330–0.444) | < 0.001 |
N1 | 0.451 (0.399–0.510) | < 0.001 | 0.445 (0.393–0.505) | < 0.001 |
N2 | 0.649 (0.519–0.812) | < 0.001 | 0.663 (0.527–0.836) | < 0.001 |
Bone metastasis | ||||
No | 0.455 (0.418–0.496) | < 0.001 | 0.448 (0.411–0.489) | < 0.001 |
Yes | 0.426 (0.295–0.616) | < 0.001 | 0.453 (0.310–0.662) | < 0.001 |
Liver metastasis | ||||
No | 0.371 (0.312–0.440) | < 0.001 | 0.358 (0.299–0.428) | < 0.001 |
Yes | 0.493 (0.449–0.542) | < 0.001 | 0.488 (0.443–0.538) | < 0.001 |
Lung metastasis | ||||
No | 0.423 (0.384–0.466) | < 0.001 | 0.420 (0.380–0.464) | < 0.001 |
Yes | 0.567 (0.485–0.664) | < 0.001 | 0.550 (0.468–0.646) | < 0.001 |
Brain metastasis | ||||
No | 0.457 (0.421–0.497) | < 0.001 | 0.452 (0.415–0.492) | < 0.001 |
Yes | 0.400 (0.151–1.060) | 0.065 | 0.338 (0.122–0.932) | 0.036 |