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Table 2 Univariate analysis of risk factors for postoperative AL in sigmoid and rectal surgery

From: Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery

  Sigmoid surgery Rectal surgery
Non-AL AL p value Non-AL AL p value
(n = 244) (n = 13) (n = 574) (n = 69)
BMI < 30 147 (96.7%) 5 (3.3%) 0.337 424 (89.8%) 48 (10.2%) 0.999
≥ 30 83 (93.3%) 6 (6.7%) 122 (89.7%) 14 (10.3%)
Gender Female 111 (94.9%) 6 (5.1%) 0.999 280 (93.3%) 20 (6.7%) 0.002
Male 133 (95.0%) 7 (5.0%) 294 (85.7%) 49 (14.3%)
ASA I–II 158 (98.8%) 2 (1.3%) 0.002 389 (90.5%) 41 (9.5%) 0.154
III–IV 76 (89.4%) 9 (10.6%) 158 (86.3%) 25 (13.7%)
CCI ≤ 5 172 (95.6%) 8 (4.4%) 0.538 430 (91.5%) 40 (8.5%) 0.004
> 5 72 (93.5%) 5 (6.5%) 144 (83.2%) 29 (16.8%)
Ischemic heart disease Yes 13 (100%) 0 (0%) 0.999 26 (86.7%) 4 (13.3%) 0.551
No 231 (94.7%) 13 (5.3%) 548 (89.4%) 65 (10.6%)
Diabetes mellitus Yes 28 (90.3%) 3 (9.7%) 0.197 54 (84.4%) 10 (15.6%) 0.200
No 216 (95.6%) 10 (4.4%) 520 (89.8%) 59 (10.2%)
History of CVD Yes 8 (100%) 0 (0.0%) 0.999 17 (89.5%) 2 (10.5%) 0.999
No 236 (94.8%) 13 (5.2%) 557 (89.3%) 67 (10.7%)
Chronic renal failure Yes 4 (100%) 0 (0.0%) 0.999 8 (88.9%) 1 (11.1%) 0.999
No 240 (94.9%) 13 (5.1%) 566 (89.3%) 68 (10.7%)
Neoadjuvant treatment Yes 8 (88.9%) 1 (11.1%) 0.378 161 (88.0%) 22 (12.0%) 0.484
No 236 (95.2%) 12 (4.8%) 413 (89.8%) 47 (10.2%)
Approach of surgery Open 71 (91.0%) 7 (9.0%) 0.069 320 (87.9%) 44 (12.1%) 0.247
MI 173 (96.6%) 6 (3.4%) 254 (91.0%) 25 (9.0%)
Anastomosis level from anal verge ≤ 5 20 (95.2%) 1 (4.8%) 0.999 155 (89.1%) 19 (10.9%) 0.137
6–12    235 (86.4%) 37 (13.6%)
> 12 178 (93.7%) 12 (6.3%) 81 (94.2%) 5 (5.8%)
Ileostomy Yes 0 (0.0%) 1 (100%) 0.051 330 (88.5%) 43 (11.5%) 0.519
No 244 (95.3%) 12 (4.7%) 244 (90.4%) 26 (9.6%)
T stage T0–T2 84 (97.7%) 2 (2.3%) 0.230 200 (93.0%) 15 (7%) 0.031
T3–T4 160 (93.6%) 11 (6.4%) 374 (87.4%) 54 (12.6%)
N stage 0 143 (96%) 6 (4.0%) 0.253 357 (91.1%) 35 (8.9%) 0.130
1 70 (97.2%) 2 (2.8%) 149 (86.6%) 23 (13.4%)
2 27 (90.0%) 3 (10%) 61 (84.7%) 11 (15.3%)
M stage 0 209 (95.9%) 9 (4.1%) 0.117 531 (89.7 %) 61 (10.3 %) 0.238
1 35 (89.7%) 4 (10.3%) 43 (84.3 %) 8 (15.7 %)
TNM stage 0 5 (100%) 0 (0.0%) 0.221 6 (85.7%) 1 (14.3%) 0.568
1 64 (97.0%) 2 (3.0%) 147 (91.9%) 13 (8.1%)
2 68 (95.8%) 3 (4.2%) 178 (89.9%) 20 (10.1%)
3 72 (96.0%) 3 (4%) 200 (88.1%) 27 (11.9%)
4 35 (87.5%) 5 (12.5%) 43 (84.3%) 8 (15.7%)
Ligation of IMA High 189 (95.9%) 8 (4.1%) 0.165 442 (88.4%) 58 (11.6%) 0.265
Low 50 (90.9%) 5 (9.1%) 117 (92.1%) 10 (7.9%)
Simultaneous operation Yes 20 (90.9%) 2 (9.1%) 0.308 53 (85.5%) 9 (14.5%) 0.286
No 224 (95.3%) 11 (4.7%) 521 (89.7%) 60 (10.3%)
Air-water test Yes 121 (96.8%) 4 (3.2%) 0.255 454 (88.7%) 58 (11.3%) 0.429
No 119 (93.0%) 9 (7.0%) 116 (91.3%) 11 (8.7%)
  1. BMI body mass index, ASA American Society of Anesthesiologists classification score, CCI Charlson comorbidity index score, CVD cardiovascular disease, MI minimally invasive, IMA inferior mesenteric artery, AL anastomotic leakage