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Table 3 Univariate and multivariate analyses of factors associated with lateral lymph node metastasis in 1773 PTC patients

From: PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis

  Univariate analysis Multivariate analysis
  LLNM (−) LLNM (+) P value Adjusted OR (95% CI) P value
  n = 948 n = 825    
Sex    < 0.001*   
 Female 713 (75.2%) 547 (66.3%)    
 Male 235 (24.8%) 278 (33.7%)   1.486 (1.184–1.867) < 0.001*
Age    0.536   
 < = 55 673 (85.4%) 616 (84.3%)    
 > 55 115 (14.6%) 115 (15.7%)    
Size (cm)    < 0.001*   
 ≤ 1 549 (57.9%) 313 (37.9%)    
 1~2 291 (30.7%) 333 (40.4%)   1.707 (1.359–2.144) < 0.001*
 > 2 108 (11.4%) 179 (21.7%)   2.496 (1.844–3.380) < 0.001*
Location    < 0.001   
 Upper 289 (30.5%) 335 (40.6%)   2.136 (1.707–2.672) < 0.001*
 Non-upper 659 (69.5%) 490 (59.4%)    
ETE 160 (16.9%) 215 (26.1%) < 0.001* 1.332 (1.031-1.72) 0.028*
Multifocality 152 (16.0%) 160 (19.4%) 0.064   
Hashimoto 136 (14.3%) 111 (13.5%) 0.589   
CLNM 511 (53.9%) 686 (83.2%) < 0.001* 4.172 (3.279–5.308) < 0.001
  1. *Symbol for p < 0.05
  2. ETE extrathyroidal extension, CLNM central lymph node metastasis, LLNM lateral lymph node metastasis, OR odds ratio, CI confidence interval