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Table 3 Univariate and multivariate analyses of factors associated with lateral lymph node metastasis in 1773 PTC patients

From: PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis

 

Univariate analysis

Multivariate analysis

 

LLNM (−)

LLNM (+)

P value

Adjusted OR (95% CI)

P value

 

n = 948

n = 825

   

Sex

  

< 0.001*

  

 Female

713 (75.2%)

547 (66.3%)

   

 Male

235 (24.8%)

278 (33.7%)

 

1.486 (1.184–1.867)

< 0.001*

Age

  

0.536

  

 < = 55

673 (85.4%)

616 (84.3%)

   

 > 55

115 (14.6%)

115 (15.7%)

   

Size (cm)

  

< 0.001*

  

 ≤ 1

549 (57.9%)

313 (37.9%)

   

 1~2

291 (30.7%)

333 (40.4%)

 

1.707 (1.359–2.144)

< 0.001*

 > 2

108 (11.4%)

179 (21.7%)

 

2.496 (1.844–3.380)

< 0.001*

Location

  

< 0.001

  

 Upper

289 (30.5%)

335 (40.6%)

 

2.136 (1.707–2.672)

< 0.001*

 Non-upper

659 (69.5%)

490 (59.4%)

   

ETE

160 (16.9%)

215 (26.1%)

< 0.001*

1.332 (1.031-1.72)

0.028*

Multifocality

152 (16.0%)

160 (19.4%)

0.064

  

Hashimoto

136 (14.3%)

111 (13.5%)

0.589

  

CLNM

511 (53.9%)

686 (83.2%)

< 0.001*

4.172 (3.279–5.308)

< 0.001

  1. *Symbol for p < 0.05
  2. ETE extrathyroidal extension, CLNM central lymph node metastasis, LLNM lateral lymph node metastasis, OR odds ratio, CI confidence interval