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Table 4 Comparison of clinicopathologic characteristics among three new classifications

From: Reclassification of tumor size for solitary HBV-related hepatocellular carcinoma by minimum p value method: a large retrospective study

Parameter ≤ 3 cm (n = 422) 3~9 cm (n = 1072) > 9 cm (n = 266) p value
≤ 3 vs. 3~9 3~9 vs. > 9 ≤ 3 vs. > 9
Age, years       
 ≤ 50 212 (50.2%) 534 (49.8%) 139 (52.3%) 0.928 0.519 0.662
 > 50 210 (49.8%) 538 (50.2%) 127 (47.7%)    
Sex       
 Male 346 (82.0%) 928 (86.6%) 223 (83.8%) 0.0303 0.293 0.604
 Female 76 (18.0%) 144 (13.4%) 43 (16.2%)    
AFP, ng/mL       
 ≤ 20 183 (43.4%) 471 (43.9%) 72 (27.1%) < 0.001 < 0.001 < 0.001
 20–400 140 (33.2%) 249 (23.2%) 62 (23.3%)    
 ≥ 400 99 (23.5%) 352 (32.8%) 132 (49.6%)    
HBV DNA, IU/ml      
 ≤ 1000 213 (50.5%) 488 (45.5%) 100 (37.6%) 0.0951 0.0236 0.00126
 > 1000 209 (49.5%) 584 (54.5%) 166 (62.4%)    
White blood cells, 109/L      
 < 4 131 (31.0%) 236 (22.0%) 41 (15.4%) < 0.001 0.0218 < 0.001
 ≥ 4 291 (69.0%) 836 (78.0%) 225 (84.6%)    
Platelet count, 109/L      
 < 100 115 (27.3%) 193 (18.0%) 15 (5.6%) < 0.001 < 0.001 < 0.001
 ≥ 100 307 (72.7%) 879 (82.0%) 251 (94.4%)    
Albumin, g/L      
 < 35 10 (2.4%) 29 (2.7%) 14 (5.3%) 0.852 0.0545 0.0717
 ≥ 35 412 (97.6%) 1043 (97.3%) 252 (94.7%)    
Total bilirubin, μmol/L      
 ≤ 17.1 314 (74.4%) 822 (76.7%) 205 (77.1%) 0.391 0.958 0.485
 > 17.1 108 (25.6%) 250 (23.3%) 61 (22.9%)    
γ-Glutamyl transferase, IU/L      
 ≤ 64 300 (71.1%) 663 (61.8%) 62 (23.3%) < 0.001 < 0.001 < 0.001
 > 64 122 (28.9%) 409 (38.2%) 204 (76.7%)    
Alkaline phosphatase, IU/L      
 ≤ 129 410 (97.2%) 998 (93.1%) 181 (68.0%) 0.00362 < 0.001 < 0.001
 > 129 12 (2.8%) 74 (6.9%) 85 (32.0%)    
ALBI grade       
 ≤ − 2.63 321 (76.1%) 795 (74.2%) 154 (57.9%) 0.486 < 0.001 < 0.001
 > 2.63 101 (23.9%) 277 (25.8%) 112 (42.1%)    
Blood loss, mL      
 < 800 417 (98.8%) 1024 (95.5%) 209 (78.6%) 0.00326 < 0.001 < 0.001
 ≥ 800 5 (1.2%) 48 (4.5%) 57 (21.4%)    
Differentiation degree      
 I/II 105 (24.9%) 174 (16.2%) 16 (6.0%) <0.001 <0.001 <0.001
 III/IV 317 (75.1%) 898 (83.8%) 250 (94.0%)    
Microvascular invasion      
 Negative 349 (82.7%) 830 (77.4%) 175 (65.8%) 0.0292 < 0.001 < 0.001
 Positive 73 (17.3%) 242 (22.6%) 91 (34.2%)    
Tumor capsule      
 Incomplete/absent 292 (69.2%) 735 (68.6%) 205 (77.1%) 0.861 0.00827 0.0309
 Complete 130 (30.8%) 337 (31.4%) 61 (22.9%)    
Cirrhosis       
 Absent 157 (37.2%) 588 (54.9%) 182 (68.4%) < 0.001 < 0.001 < 0.001
 Present 265 (62.8%) 484 (45.1%) 84 (31.6%)