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Table 4 Comparison of clinicopathologic characteristics among three new classifications

From: Reclassification of tumor size for solitary HBV-related hepatocellular carcinoma by minimum p value method: a large retrospective study

Parameter

≤ 3 cm (n = 422)

3~9 cm (n = 1072)

> 9 cm (n = 266)

p value

≤ 3 vs. 3~9

3~9 vs. > 9

≤ 3 vs. > 9

Age, years

      

 ≤ 50

212 (50.2%)

534 (49.8%)

139 (52.3%)

0.928

0.519

0.662

 > 50

210 (49.8%)

538 (50.2%)

127 (47.7%)

   

Sex

      

 Male

346 (82.0%)

928 (86.6%)

223 (83.8%)

0.0303

0.293

0.604

 Female

76 (18.0%)

144 (13.4%)

43 (16.2%)

   

AFP, ng/mL

      

 ≤ 20

183 (43.4%)

471 (43.9%)

72 (27.1%)

< 0.001

< 0.001

< 0.001

 20–400

140 (33.2%)

249 (23.2%)

62 (23.3%)

   

 ≥ 400

99 (23.5%)

352 (32.8%)

132 (49.6%)

   

HBV DNA, IU/ml

     

 ≤ 1000

213 (50.5%)

488 (45.5%)

100 (37.6%)

0.0951

0.0236

0.00126

 > 1000

209 (49.5%)

584 (54.5%)

166 (62.4%)

   

White blood cells, 109/L

     

 < 4

131 (31.0%)

236 (22.0%)

41 (15.4%)

< 0.001

0.0218

< 0.001

 ≥ 4

291 (69.0%)

836 (78.0%)

225 (84.6%)

   

Platelet count, 109/L

     

 < 100

115 (27.3%)

193 (18.0%)

15 (5.6%)

< 0.001

< 0.001

< 0.001

 ≥ 100

307 (72.7%)

879 (82.0%)

251 (94.4%)

   

Albumin, g/L

     

 < 35

10 (2.4%)

29 (2.7%)

14 (5.3%)

0.852

0.0545

0.0717

 ≥ 35

412 (97.6%)

1043 (97.3%)

252 (94.7%)

   

Total bilirubin, μmol/L

     

 ≤ 17.1

314 (74.4%)

822 (76.7%)

205 (77.1%)

0.391

0.958

0.485

 > 17.1

108 (25.6%)

250 (23.3%)

61 (22.9%)

   

γ-Glutamyl transferase, IU/L

     

 ≤ 64

300 (71.1%)

663 (61.8%)

62 (23.3%)

< 0.001

< 0.001

< 0.001

 > 64

122 (28.9%)

409 (38.2%)

204 (76.7%)

   

Alkaline phosphatase, IU/L

     

 ≤ 129

410 (97.2%)

998 (93.1%)

181 (68.0%)

0.00362

< 0.001

< 0.001

 > 129

12 (2.8%)

74 (6.9%)

85 (32.0%)

   

ALBI grade

      

 ≤ − 2.63

321 (76.1%)

795 (74.2%)

154 (57.9%)

0.486

< 0.001

< 0.001

 > 2.63

101 (23.9%)

277 (25.8%)

112 (42.1%)

   

Blood loss, mL

     

 < 800

417 (98.8%)

1024 (95.5%)

209 (78.6%)

0.00326

< 0.001

< 0.001

 ≥ 800

5 (1.2%)

48 (4.5%)

57 (21.4%)

   

Differentiation degree

     

 I/II

105 (24.9%)

174 (16.2%)

16 (6.0%)

<0.001

<0.001

<0.001

 III/IV

317 (75.1%)

898 (83.8%)

250 (94.0%)

   

Microvascular invasion

     

 Negative

349 (82.7%)

830 (77.4%)

175 (65.8%)

0.0292

< 0.001

< 0.001

 Positive

73 (17.3%)

242 (22.6%)

91 (34.2%)

   

Tumor capsule

     

 Incomplete/absent

292 (69.2%)

735 (68.6%)

205 (77.1%)

0.861

0.00827

0.0309

 Complete

130 (30.8%)

337 (31.4%)

61 (22.9%)

   

Cirrhosis

      

 Absent

157 (37.2%)

588 (54.9%)

182 (68.4%)

< 0.001

< 0.001

< 0.001

 Present

265 (62.8%)

484 (45.1%)

84 (31.6%)

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