Skip to main content

Table 3 Meta-analysis of the association between COX-2 rs689466 polymorphism and colorectal cancer risk

From: COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis

Variables No. Allele model Dominant model Recessive model Homozygous model Heterozygous model
OR (95% CI) phet OR (95% CI) phet OR (95% CI) phet OR (95% CI) phet OR (95% CI) phet
Ethnicity
 Caucasian 12 1.15 (1.02, 1.29) < 0.001 1.14 (1.00, 1.30) < 0.001 1.23 (0.99, 1.53) 0.138 1.28 (1.00, 1.65) 0.042 1.11 (0.98, 1.25) 0.005
 Asian 4 0.82 (0.67, 1.01) 0.004 0.89 (0.65, 1.22) 0.006 0.76 (0.52, 1.11) 0.002 0.75 (0.46, 1.21) 0.001 0.94 (0.70, 1.26) 0.024
SOC
 PB 10 1.03 (0.91, 1.18) < 0.001 1.01 (0.88, 1.16) < 0.001 1.10 (0.86, 1.41) 0.001 1.10 (0.80, 1.52) < 0.001 1.00 (0.88, 1.12) 0.002
 HB 6 1.14 (0.84, 1.54) < 0.001 1.32 (0.95, 1.83) 0.002 1.03 (0.60, 1.76) 0.001 1.17 (0.65, 2.10) 0.002 1.33 (1.00, 1.78) 0.022
HWE
 Positive 14 1.09 (0.96, 1.23) < 0.001 1.12 (0.99, 1.27) < 0.001 1.11 (0.85, 1.46) < 0.001 1.17 (0.89, 1.55) < 0.001 1.11 (0.99, 1.24) 0.008
 Negative 2 0.90 (0.64, 1.26) 0.001 0.83 (0.52, 1.35) 0.003 0.90 (0.57, 1.40) 0.016 0.81 (0.40, 1.64) 0.001 0.84 (0.57, 1.25) 0.021
Genotyping
 Pyrosequencing 2 1.04 (0.72, 1.50) 0.014 1.04 (0.70, 1.56) 0.024 1.04 (0.58, 1.88) 0.135 1.07 (0.52, 2.19) 0.076 1.03 (0.72, 1.47) 0.058
 PCR-RFLR 8 1.02 (0.83, 1.25) < 0.001 1.11 (0.85, 1.44) < 0.001 0.94 (0.67, 1.32) < 0.001 0.99 (0.65, 1.51) < 0.001 1.12 (0.88, 1.42) < 0.001
 Taqman 4 1.11 (0.87, 1.40) 0.005 1.10 (0.85, 1.42) 0.024 1.25 (0.80, 1.95) 0.281 1.28 (0.76, 2.16) 0.009 1.07 (0.86, 1.34) 0.116
 Other methods 2 1.18 (0.86, 1.60) 0.008 1.12 (0.91, 1.37) 0.124 1.39 (0.62, 3.10) 0.018 1.44 (0.61, 3.38) 0.013 1.07 (0.96, 1.18) 0.333
  1. OR odds ratio, CI confidence interval, SOC source of controls, HB hospital-based controls, PB population-based controls, HWE Hardy–Weinberg equilibrium, PCR-RFLR polymerase chain reaction-restriction fragment length polymorphism