COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis

Table 3 Meta-analysis of the association between COX-2 rs689466 polymorphism and colorectal cancer risk

Variables	No.	Allele model		Dominant model		Recessive model		Homozygous model		Heterozygous model
Variables	No.	OR (95% CI)	p^het	OR (95% CI)	p^het	OR (95% CI)	p^het	OR (95% CI)	p^het	OR (95% CI)	p^het
Ethnicity
Caucasian	12	1.15 (1.02, 1.29)	< 0.001	1.14 (1.00, 1.30)	< 0.001	1.23 (0.99, 1.53)	0.138	1.28 (1.00, 1.65)	0.042	1.11 (0.98, 1.25)	0.005
Asian	4	0.82 (0.67, 1.01)	0.004	0.89 (0.65, 1.22)	0.006	0.76 (0.52, 1.11)	0.002	0.75 (0.46, 1.21)	0.001	0.94 (0.70, 1.26)	0.024
SOC
PB	10	1.03 (0.91, 1.18)	< 0.001	1.01 (0.88, 1.16)	< 0.001	1.10 (0.86, 1.41)	0.001	1.10 (0.80, 1.52)	< 0.001	1.00 (0.88, 1.12)	0.002
HB	6	1.14 (0.84, 1.54)	< 0.001	1.32 (0.95, 1.83)	0.002	1.03 (0.60, 1.76)	0.001	1.17 (0.65, 2.10)	0.002	1.33 (1.00, 1.78)	0.022
HWE
Positive	14	1.09 (0.96, 1.23)	< 0.001	1.12 (0.99, 1.27)	< 0.001	1.11 (0.85, 1.46)	< 0.001	1.17 (0.89, 1.55)	< 0.001	1.11 (0.99, 1.24)	0.008
Negative	2	0.90 (0.64, 1.26)	0.001	0.83 (0.52, 1.35)	0.003	0.90 (0.57, 1.40)	0.016	0.81 (0.40, 1.64)	0.001	0.84 (0.57, 1.25)	0.021
Genotyping
Pyrosequencing	2	1.04 (0.72, 1.50)	0.014	1.04 (0.70, 1.56)	0.024	1.04 (0.58, 1.88)	0.135	1.07 (0.52, 2.19)	0.076	1.03 (0.72, 1.47)	0.058
PCR-RFLR	8	1.02 (0.83, 1.25)	< 0.001	1.11 (0.85, 1.44)	< 0.001	0.94 (0.67, 1.32)	< 0.001	0.99 (0.65, 1.51)	< 0.001	1.12 (0.88, 1.42)	< 0.001
Taqman	4	1.11 (0.87, 1.40)	0.005	1.10 (0.85, 1.42)	0.024	1.25 (0.80, 1.95)	0.281	1.28 (0.76, 2.16)	0.009	1.07 (0.86, 1.34)	0.116
Other methods	2	1.18 (0.86, 1.60)	0.008	1.12 (0.91, 1.37)	0.124	1.39 (0.62, 3.10)	0.018	1.44 (0.61, 3.38)	0.013	1.07 (0.96, 1.18)	0.333

OR odds ratio, CI confidence interval, SOC source of controls, HB hospital-based controls, PB population-based controls, HWE Hardy–Weinberg equilibrium, PCR-RFLR polymerase chain reaction-restriction fragment length polymorphism

ISSN: 1477-7819