Table 2 The association between COX-2 rs689466 polymorphism and colorectal cancer risk under different genetic models
Genetic models | OR (95% CI) | p (OR) | Model | I2 (%) | p (H) |
|---|---|---|---|---|---|
Allele model (G vs. A) | 1.06 (0.94, 1.19) | 0.363 | Random | 81.7 | < 0.001 |
Dominant model (GG + AG vs. AA) | 1.08 (0.95, 1.24) | 0.237 | Random | 75.9 | < 0.001 |
Recessive model (GG vs. AG + AA) | 1.06 (0.84, 1.32) | 0.627 | Random | 66.8 | < 0.001 |
Homozygous model (GG vs. AA) | 1.10 (0.84, 1.44) | 0.478 | Random | 73.5 | < 0.001 |
Heterozygous model (AG vs. AA) | 1.07 (0.95, 1.21) | 0.257 | Random | 66.5 | < 0.001 |