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Table 1 Characteristic of studies on the association between COX-2 rs689466 polymorphism and colorectal cancer

From: COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis

Author and year Country Ethnicity SOC Genotyping method Case Control p values* HWE NOS
AA AG GG AA AG GG
Siezen et al. [16], 2005 Netherlands Caucasian PB Pyrosequencing 218 131 22 255 122 16 > 0.05 0.77 7
Siezen et al. [16, 17], 2006 Netherlands Caucasian PB Pyrosequencing 410 191 29 665 354 61 > 0.05 0.13 6
Tan et al. [15], 2007 China Asian PB PCR-RFLR 320 502 178 308 692 300 < 0.05 0.02 6
Andersen et al. [24], 2009 Denmark Caucasian PB Taqman QPCR 230 116 13 482 258 25 0.88 0.177 7
Hoff et al. [23], 2009 Netherlands Caucasian PB PCR-RFLR 213 101 12 232 124 13 0.99 0.471 8
Thompson et al. [14], 2009 USA Caucasian PB Taqman 275 138 9 297 168 15 0.99 0.131 7
Pereira et al. [20], 2010 Portugal Caucasian HB PCR-RFLR 70 43 4 177 73 6 0.078 0.634 7
Zhang et al. [10], 2012 China Asian HB PCR-RFLR 77 216 50 62 184 94 < 0.05 0.09 6
Ruan et al. [11], 2013 China Asian HB PCR-RFLR 34 67 29 39 53 28 0.847 0.232 6
Andersen et al. [25], 2013 Denmark Caucasian PB PCR 587 313 47 1126 560 61 0.09 0.397 7
Li et al. [22], 2013 China Asian HB PCR-RFLR 116 248 87 179 366 114 0.34 0.002 6
Makar et al. [21], 2013 USA Caucasian PB Illumina 1529 742 90 2156 1005 130 > 0.05 0.343 8
Pereira et al. [19, 29], 2014 Portugal Caucasian PB Taqman 143 85 15 323 133 16 0.076 0.614 7
Vogel et al. [12], 2014 Norway Caucasian PB KASPTM 626 284 23 209 114 11 0.262 0.337 8
Shomaf et al. [18], 2015 Jordan Caucasian HB PCR-RFLR 68 61 6 87 27 1 0.13 0.483 7
Tomitao et al. [13], 2017 Brazil Caucasian HB Taqman 146 72 12 135 55 6 0.17 0.89 7
  1. HB hospital-based controls, PB population-based controls, SOC source of controls, PCR-RFLR polymerase chain reaction-restriction fragment length polymorphism, KASPTM kompetitive allele-specific polymerase chain reaction, QPCR quantitative real-time polymerase chain reaction, HWE Hardy–Weinberg equilibrium, NOS Newcastle–Ottawa Scale
  2. *p values for the association between COX-2 gene rs689466 polymorphism and colorectal cancer risk from original article