COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis

Table 1 Characteristic of studies on the association between COX-2 rs689466 polymorphism and colorectal cancer

Author and year	Country	Ethnicity	SOC	Genotyping method	Case			Control			p values*	HWE	NOS
Author and year	Country	Ethnicity	SOC	Genotyping method	AA	AG	GG	AA	AG	GG	p values*	HWE	NOS
Siezen et al. [16], 2005	Netherlands	Caucasian	PB	Pyrosequencing	218	131	22	255	122	16	> 0.05	0.77	7
Siezen et al. [16, 17], 2006	Netherlands	Caucasian	PB	Pyrosequencing	410	191	29	665	354	61	> 0.05	0.13	6
Tan et al. [15], 2007	China	Asian	PB	PCR-RFLR	320	502	178	308	692	300	< 0.05	0.02	6
Andersen et al. [24], 2009	Denmark	Caucasian	PB	Taqman QPCR	230	116	13	482	258	25	0.88	0.177	7
Hoff et al. [23], 2009	Netherlands	Caucasian	PB	PCR-RFLR	213	101	12	232	124	13	0.99	0.471	8
Thompson et al. [14], 2009	USA	Caucasian	PB	Taqman	275	138	9	297	168	15	0.99	0.131	7
Pereira et al. [20], 2010	Portugal	Caucasian	HB	PCR-RFLR	70	43	4	177	73	6	0.078	0.634	7
Zhang et al. [10], 2012	China	Asian	HB	PCR-RFLR	77	216	50	62	184	94	< 0.05	0.09	6
Ruan et al. [11], 2013	China	Asian	HB	PCR-RFLR	34	67	29	39	53	28	0.847	0.232	6
Andersen et al. [25], 2013	Denmark	Caucasian	PB	PCR	587	313	47	1126	560	61	0.09	0.397	7
Li et al. [22], 2013	China	Asian	HB	PCR-RFLR	116	248	87	179	366	114	0.34	0.002	6
Makar et al. [21], 2013	USA	Caucasian	PB	Illumina	1529	742	90	2156	1005	130	> 0.05	0.343	8
Pereira et al. [19, 29], 2014	Portugal	Caucasian	PB	Taqman	143	85	15	323	133	16	0.076	0.614	7
Vogel et al. [12], 2014	Norway	Caucasian	PB	KASPTM	626	284	23	209	114	11	0.262	0.337	8
Shomaf et al. [18], 2015	Jordan	Caucasian	HB	PCR-RFLR	68	61	6	87	27	1	0.13	0.483	7
Tomitao et al. [13], 2017	Brazil	Caucasian	HB	Taqman	146	72	12	135	55	6	0.17	0.89	7

HB hospital-based controls, PB population-based controls, SOC source of controls, PCR-RFLR polymerase chain reaction-restriction fragment length polymorphism, KASPTM kompetitive allele-specific polymerase chain reaction, QPCR quantitative real-time polymerase chain reaction, HWE Hardy–Weinberg equilibrium, NOS Newcastle–Ottawa Scale
*p values for the association between COX-2 gene rs689466 polymorphism and colorectal cancer risk from original article

ISSN: 1477-7819