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Table 3 Univariate and multivariate analysis of factors to predict impaired DSS in oldest patients with CLRMs

From: Multidisciplinary treatment for colorectal liver metastases in elderly patients

Variable Univariate analysis Multivariate analysis
p value p value HR (95%CI)
Patients Sex, male 0.124   
Age ≥ 75 0.038 0.0005 3.231 (1.725-5.758)
Preoperative factors CEA ≥ 5 0.037   
No preoperative chemotherapy 0.011   
Primary tumor Site: rectum 0.245   
N positive < 0.01   
Tumor differentiation: poorly 0.0061   
Liver metastases Synchronous 0.932   
Size ≥ 2 cm 0.0002   
Number ≥ 2 < 0.01   
Perioperative factors Non-PSH approach 0.049   
Operative time > 180 min 0.004   
Blood loss > 500 0.006   
Surgical margin: positive 0.0003   
Major complications 0.001   
Postoperative factors DFI from 1st hepatectomy < 1 year < 0.01 < 0.01 2.951 (1.778-5.163)
No postoperative chemotherapy 0.94   
  1. CRLMs colorectal cancer liver metastases; DSS disease-specific survival; N lymph node; PSH parenchymal-sparing hepatectomy; DFI disease-free interval