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Table 3 Univariate and multivariate analysis of factors to predict impaired DSS in oldest patients with CLRMs

From: Multidisciplinary treatment for colorectal liver metastases in elderly patients

Variable

Univariate analysis

Multivariate analysis

p value

p value

HR (95%CI)

Patients

Sex, male

0.124

  

Age ≥ 75

0.038

0.0005

3.231 (1.725-5.758)

Preoperative factors

CEA ≥ 5

0.037

  

No preoperative chemotherapy

0.011

  

Primary tumor

Site: rectum

0.245

  

N positive

< 0.01

  

Tumor differentiation: poorly

0.0061

  

Liver metastases

Synchronous

0.932

  

Size ≥ 2 cm

0.0002

  

Number ≥ 2

< 0.01

  

Perioperative factors

Non-PSH approach

0.049

  

Operative time > 180 min

0.004

  

Blood loss > 500

0.006

  

Surgical margin: positive

0.0003

  

Major complications

0.001

  

Postoperative factors

DFI from 1st hepatectomy < 1 year

< 0.01

< 0.01

2.951 (1.778-5.163)

No postoperative chemotherapy

0.94

  
  1. CRLMs colorectal cancer liver metastases; DSS disease-specific survival; N lymph node; PSH parenchymal-sparing hepatectomy; DFI disease-free interval