From: Multidisciplinary treatment for colorectal liver metastases in elderly patients
Variable | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
p value | p value | HR (95%CI) | ||
Patients | Sex, male | 0.124 | Â | Â |
Age ≥ 75 | 0.038 | 0.0005 | 3.231 (1.725-5.758) | |
Preoperative factors | CEA ≥ 5 | 0.037 |  |  |
No preoperative chemotherapy | 0.011 | Â | Â | |
Primary tumor | Site: rectum | 0.245 | Â | Â |
N positive | < 0.01 | Â | Â | |
Tumor differentiation: poorly | 0.0061 | Â | Â | |
Liver metastases | Synchronous | 0.932 | Â | Â |
Size ≥ 2 cm | 0.0002 |  |  | |
Number ≥ 2 | < 0.01 |  |  | |
Perioperative factors | Non-PSH approach | 0.049 | Â | Â |
Operative time > 180 min | 0.004 |  |  | |
Blood loss > 500 | 0.006 | Â | Â | |
Surgical margin: positive | 0.0003 | Â | Â | |
Major complications | 0.001 | Â | Â | |
Postoperative factors | DFI from 1st hepatectomy < 1 year | < 0.01 | < 0.01 | 2.951 (1.778-5.163) |
No postoperative chemotherapy | 0.94 | Â | Â |