Table 3 Univariate and multivariate analysis of factors to predict impaired DSS in oldest patients with CLRMs
From: Multidisciplinary treatment for colorectal liver metastases in elderly patients
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| p value | p value | HR (95%CI) | ||
| Patients | Sex, male | 0.124 | ||
| Age ≥ 75 | 0.038 | 0.0005 | 3.231 (1.725-5.758) | |
| Preoperative factors | CEA ≥ 5 | 0.037 | ||
| No preoperative chemotherapy | 0.011 | |||
| Primary tumor | Site: rectum | 0.245 | ||
| N positive | < 0.01 | |||
| Tumor differentiation: poorly | 0.0061 | |||
| Liver metastases | Synchronous | 0.932 | ||
| Size ≥ 2 cm | 0.0002 | |||
| Number ≥ 2 | < 0.01 | |||
| Perioperative factors | Non-PSH approach | 0.049 | ||
| Operative time > 180 min | 0.004 | |||
| Blood loss > 500 | 0.006 | |||
| Surgical margin: positive | 0.0003 | |||
| Major complications | 0.001 | |||
| Postoperative factors | DFI from 1st hepatectomy < 1 year | < 0.01 | < 0.01 | 2.951 (1.778-5.163) |
| No postoperative chemotherapy | 0.94 | |||