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Table 3 Cox proportional hazards models for factors predictive of survival outcomes

From: The importance of primary tumor origin in gastrointestinal malignancies undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Outcome

Variable

Multivariate analysis

HR (CI)

p value

OSa

PC primary tumor origin

  

 Gastric

1.60 (0.52–4.88)

0.411

 Appendiceal

0.34 (0.11–1.02)

0.054

 Colorectal

0.45 (0.15–1.33)

0.150

Complete cytoreduction

0.27 (0.12–0.63)

< 0.001*

Tumor recurrence

2.73 (1.58–4.73)

< 0.001*

PCI score

1.08 (1.03–1.14)

0.002*

PCI < 12

2.28 (1.01–5.12)

0.047*

PFS

0.89 (0.87–0.92)

< 0.001*

PFSb

PC primary tumor origin

  

 Gastric

0.84 (0.36–1.98)

0.694

 Appendix

0.45 (0.21–1.00)

0.230

 Colorectal

0.62 (0.29–1.35)

0.049*

PCI score

1.05 (1.03–1.07)

< 0.001*

  1. HR hazard ratio, CI confidence intervals, OS overall survival, PC peritoneal carcinomatosis, PCI peritoneal cancer index, PFS progression-free survival
  2. *p < 0.05
  3. Univariate non-significant predictors excluded from multivariate analysis
  4. aNeoadjuvant chemotherapy, length of stay, adjuvant chemotherapy, perioperative complication
  5. bNeoadjuvant chemotherapy, PCI < 12, complete cytoreduction, length of stay, adjuvant chemotherapy, perioperative complication