Fig. 4

The analysis of postoperative comprehensive genomic profiling. a The summary of gene mutation abundance indicated that most of the gene mutation abundance from the specimen of reoperation was higher than the specimen of primary operation. b The mutation was divided into 8 clones (0–7) according to the information of mutation abundance and mutation types. Most clones of reoperation specimen were derived from the primary tumor specimen, and some added clones can be seen (marked in red frame), indicating that the metastases evolved from the primary foci