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Table 2 Cox proportional hazards regression analysis for OS

From: Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases

Variates Univariate analysis Multivariate analysis
HR 95% CI p HR 95% CI p
Sources
 Urban Ref Ref Ref Ref Ref Ref
 Country 1.221 1.0212–1.4598 0.0293 1.0272 0.8533–1.2364 0.7779
Ages (years)       NI
 < 60 Ref Ref Ref    
 60–69 0.9238 0.7541–1.1316 0.4461    
 ≥ 70 1.0349 0.8269–1.2952 0.08909    
Sex       NI
 Female Ref Ref Ref    
 Male 0.883 0.7374–1.0573 0.1781    
BMI (Kg/m2)       NI
 < 28 Ref Ref Ref    
 ≥ 28 1.1157 0.8557–1.4548 0.4211    
 Unknown 0.4844 0.2595–0.9043 0.0236    
Smoking history       NI
 No Ref Ref Ref    
 Yes 1.0663 0.8604–1.3215 0.5596    
Gallbladder location of tumor
 Fundus Ref Ref Ref Ref Ref Ref
 Body 1.5472 1.2442–1.9241 0.0001 1.4901 1.1858–1.8726 0.0007
 Neck 1.4257 1.0976–1.8519 0.0082 1.1776 0.8959–1.5479 0.2437
 Unknown 1.445 0.9751–2.1412 0.068 0.6761 0.4434–1.0310 0.0705
Clinical staging
 I Ref Ref Ref Ref Ref Ref
 II 2.9912 1.1632–7.6921 0.0237 2.9253 1.1281–7.5861 0.0281
 III 7.3437 3.0318–17.7882 < 0.0001 6.4359 2.6198–15.8108 0.0001
 IV 16.4044 6.7898–39.6340 < 0.0001 10.4364 4.1505–26.2422 < 0.0001
T stage       NI
 T1 Ref Ref Ref    
 T2 2.2162 0.9901–4.9607 0.0541    
 T3 5.6811 2.6900–11.9979 < 0.0001    
 T4 9.2513 4.3199–19.8121 < 0.0001    
 Unknown 12.0606 5.5666–26.1303 < 0.0001    
N stage       NI
 N0 Ref Ref Ref    
 N1 2.4167 1.7968–3.2505 0.017    
 N2 4.2985 3.2423–5.6989 <  0.0001    
 Unknown 3.1367 2.5164–3.9099 < 0.0001    
M stage       NI
 M0 Ref Ref Ref    
 M1 2.4876 2.0433–3.0286 < 0.0001    
 Unknown 1.4786 1.0065–2.1721 0.0474    
Grade
 Well-differentiated Ref Ref Ref Ref Ref Ref
 Moderately differentiated 1.4133 0.7651–2.6107 0.2717 1.3022 0.6944–2.4420 0.4128
 Poorly differentiated 2.3874 1.3269–4.2957 0.0039 1.7171 0.9330–3.1604 0.0839
 Unknown 2.4023 1.3517–4.2694 0.003 1.5552 0.8560–2.8257 0.1493
CA199
 < 27 U/mL Ref Ref Ref Ref Ref Ref
 ≥ 27 U/mL 2.2785 1.8655–2.7830 < 0.0001 1.3941 1.0838–1.7933 0.0101
 Unknown 1.3304 0.9374–1.8881 0.1118 1.2309 0.6981–2.1705 0.475
CA242
 < 20 IU/mL Ref Ref Ref Ref Ref Ref
 ≥ 20 IU/mL 1.9779 1.6322–2.3969 < 0.0001 1.1169 0.8790–1.4192 0.3679
 Unknown 1.042 0.7776–1.3964 0.7838 1.0146 0.6312–1.6310 0.9525
With chronic disease       NI
 No Ref Ref Ref    
 Yes 0.8733 0.7292–1.0460 0.1432    
Gallstone       NI
 No Ref Ref Ref    
 Yes 0.9403 0.7885–1.1213 0.4955    
Adjuvant therapy       NI
 None Ref Ref Ref    
 Received 0.8719 0.7105–1.0699 0.1916    
Surgery
 Simple resection Ref Ref Ref Ref Ref Ref
 Radical resection 1.3679 1.0384–1.8021 0.0267 1.0397 0.7820–1.3823 0.7898
 Palliative surgery 3.3214 2.5191–4.3792 < 0.0001 1.41 0.9886–2.0111 0.0592
  1. Ref reference, CI confidence interval, NI not included in the multivariate survival analysis