| Predictors | Full model | Reduced model |
|---|
| HR | 95% CI | P value | HR | 95% CI | P value |
|---|
| Age group (years) |
| ≤ 60 | 1.00 | Reference | | 1.00 | Reference | |
| > 60 | 2.13 | 0.99, 4.54 | 0.052 | 1.77 | 0.97, 3.23 | 0.062 |
| Karnofskys Performance Status |
| Good | 1.00 | Reference | | 1.00 | Reference | |
| Moderate | 1.86 | 0.71, 4.88 | 0.204 | 2.00 | 0.96, 4.18 | 0.066 |
| Poor | 3.64 | 1.61, 8.21 | 0.002 | 2.96 | 1.48, 5.92 | 0.002 |
| Cirrhosis |
| No | 1.00 | Reference | | | Not included | |
| Yes | 1.20 | 0.60, 2.39 | 0.600 | | | |
| Ascites |
| No | 1.00 | Reference | | | Not included | |
| Yes | 1.05 | 0.32, 3.42 | 0.935 | | | |
| Total bilirubin (mg/dL) |
| < 2.0 | 1.00 | Reference | | 1.00 | Reference | |
| 2.0–3.0 | 3.27 | 0.20, 12.59 | 0.085 | 2.22 | 0.82, 5.99 | 0.114 |
| > 3.0 | 9.22 | 2.46, 34.50 | 0.001 | 10.44 | 3.92, 27.82 | < 0.001 |
| Serum albumin (mg/dL) |
| > 3.5 | 1.00 | Reference | | | Not included | |
| 2.8–3.5 | 0.80 | 0.34, 1.91 | 0.619 | | | |
| < 2.8 | 2.66 | 1.05, 6.71 | 0.039 | | | |
| Number of primary tumor |
| Single tumor | 1.00 | Reference | | 1.00 | Reference | |
| Multiple tumor | 3.42 | 1.23, 9.51 | 0.019 | 2.63 | 1.29, 5.35 | 0.008 |
| Portal vein involvement |
| No | 1.00 | Reference | | | Not included | |
| Yes | 1.46 | 0.75, 2.85 | 0.265 | | | |
| Visceral organ metastasis |
| No | 1.00 | Reference | | | Not included | |
| Yes | 1.19 | 0.85, 1.67 | 0.301 | | | |
| Number of vertebral columns involved |
| 1 | 1.00 | Reference | | | Not included | |
| 2 | 1.10 | 0.52, 2.32 | 0.807 | | | |
| ≥ 3 | 1.70 | 0.69, 4.16 | 0.248 | | | |
| Number of extraspinal bone metastases |
| 0 | 1.00 | Reference | | | Not included | |
| 1–2 | 0.93 | 0.31, 2.78 | 0.892 | | | |
| ≥ 3 | 1.03 | 0.33, 3.19 | 0.964 | | | |
- Abbreviations: HR hazard ratio, CI confidence interval
