Table 2 Estimated hazard ratios in the full and reduced multivariable flexible parametric regression models
Predictors | Full model | Reduced model | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age group (years) | ||||||
 ≤ 60 | 1.00 | Reference |  | 1.00 | Reference |  |
 > 60 | 2.13 | 0.99, 4.54 | 0.052 | 1.77 | 0.97, 3.23 | 0.062 |
Karnofskys Performance Status | ||||||
 Good | 1.00 | Reference |  | 1.00 | Reference |  |
 Moderate | 1.86 | 0.71, 4.88 | 0.204 | 2.00 | 0.96, 4.18 | 0.066 |
 Poor | 3.64 | 1.61, 8.21 | 0.002 | 2.96 | 1.48, 5.92 | 0.002 |
Cirrhosis | ||||||
 No | 1.00 | Reference |  |  | Not included |  |
 Yes | 1.20 | 0.60, 2.39 | 0.600 |  |  |  |
Ascites | ||||||
 No | 1.00 | Reference |  |  | Not included |  |
 Yes | 1.05 | 0.32, 3.42 | 0.935 |  |  |  |
Total bilirubin (mg/dL) | ||||||
 < 2.0 | 1.00 | Reference |  | 1.00 | Reference |  |
 2.0–3.0 | 3.27 | 0.20, 12.59 | 0.085 | 2.22 | 0.82, 5.99 | 0.114 |
 > 3.0 | 9.22 | 2.46, 34.50 | 0.001 | 10.44 | 3.92, 27.82 | < 0.001 |
Serum albumin (mg/dL) | ||||||
 > 3.5 | 1.00 | Reference |  |  | Not included |  |
 2.8–3.5 | 0.80 | 0.34, 1.91 | 0.619 |  |  |  |
 < 2.8 | 2.66 | 1.05, 6.71 | 0.039 |  |  |  |
Number of primary tumor | ||||||
 Single tumor | 1.00 | Reference |  | 1.00 | Reference |  |
 Multiple tumor | 3.42 | 1.23, 9.51 | 0.019 | 2.63 | 1.29, 5.35 | 0.008 |
Portal vein involvement | ||||||
 No | 1.00 | Reference |  |  | Not included |  |
 Yes | 1.46 | 0.75, 2.85 | 0.265 |  |  |  |
Visceral organ metastasis | ||||||
 No | 1.00 | Reference |  |  | Not included |  |
 Yes | 1.19 | 0.85, 1.67 | 0.301 |  |  |  |
Number of vertebral columns involved | ||||||
 1 | 1.00 | Reference |  |  | Not included |  |
 2 | 1.10 | 0.52, 2.32 | 0.807 |  |  |  |
 ≥ 3 | 1.70 | 0.69, 4.16 | 0.248 |  |  |  |
Number of extraspinal bone metastases | ||||||
 0 | 1.00 | Reference |  |  | Not included |  |
 1–2 | 0.93 | 0.31, 2.78 | 0.892 |  |  |  |
 ≥ 3 | 1.03 | 0.33, 3.19 | 0.964 |  |  |  |