Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma

Table 3 Factors predicting DFS

Items	Cox’s proportional hazard regression model
	P value	HR	95%CI
	P value	HR	Lower	Higher
Univariate Cox’s regression
CCT6A high	<0.001	1.802	1.434	2.265
Age (>60.0 years)	0.019	1.314	1.047	1.649
Male	0.064	1.297	0.985	1.708
History of smoke	0.326	0.892	0.711	1.120
History of drink	0.347	1.117	0.887	1.405
Hypertension	0.386	0.902	0.714	1.139
Hyperlipidemia	0.823	0.973	0.762	1.241
Diabetes	0.363	0.864	0.631	1.183
Poor differentiation	0.002	1.306	1.102	1.548
Tumor size (>5.0 cm)	0.008	1.363	1.083	1.715
LYN metastasis	<0.001	2.383	1.883	3.016
Higher TNM stage	<0.001	1.448	1.265	1.658
Abnormal CEA (>5.0 ng/mL)	0.002	1.434	1.138	1.806
Forward stepwise multivariate Cox’s regression
CCT6A high	<0.001	1.659	1.318	2.089
Poor differentiation	0.006	1.281	1.073	1.530
LYN metastasis	<0.001	2.227	1.757	2.824
Abnormal CEA (>5.0 ng/mL)	0.004	1.405	1.114	1.772

Factors predicting DFS were analyzed by univariate Cox’s proportional hazard regression models. The factors with P < 0.05 in univariate Cox’s regression were further analyzed in forward stepwise multivariate Cox’s regression. DFS disease-free survival; HR hazard ratio; CI confidence interval; CCT6A chaperonin containing TCP1 subunit 6A; LYN lymph node; CEA carcinoembryonic antigen

ISSN: 1477-7819