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Table 1 Main characteristics and results of the eligible studies

From: Survival outcomes of neoadjuvant versus adjuvant chemotherapy in triple-negative breast cancer: a meta-analysis of 36,480 cases

First author

Year

Country

Study type

N

Clinical stage

Chemotherapy regimen

pCR rate

Follow-up (median) (year)

HR estimation

Outcomes

Clifton

2018

USA

Prospective

319

I–II

A/T

0.538

6.33

Survival curve

OS, DFS

Fisher

2012

USA

Retrospective

385

I–III

NA

0.17

2.5

Survival curve

OS

Kennedy

2010

USA

Retrospective

405

I–III

NA

NR

4.3

Survival curve

OS

Sharma

2015

USA

Retrospective

146

I–II

A/T

NR

3.08

Given by author

DFS

Cheng

2017

NR

Retrospective

15,483

I–III

NA

NR

2

Given by author

OS

Yang

2018

China

Prospective

67

II–III

A/T

0.194

6.5

Given by author

OS

Biswas

2017

USA

Retrospective

420

I–III

A/T

0.33

3.9

Survival curve

OS

Bagegni

2019

USA

Retrospective

19,151

II-III

NA

0.474

2.5

Survival curve

OS

Philipovskiy

2019

USA

Retrospective

104

I–III

A/T

0.4

6

Given by author

OS,DFS

  1. NR not reported, A/T adriamycin/taxane, OS overall survival, DFS disease-free survival