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Table 5 Results of meta-analysis comparing NPBD versus PBD for hCCA

From: The effect and safety of preoperative biliary drainage in patients with hilar cholangiocarcinoma: an updated meta-analysis

Outcome of interest No. of studies No. of patients OR/WMD 95% CI P value Heterogeneity P value I2
Primary outcomes        
Mortality 16 775/1085 0.91 0.64, 1.30 0.62 0.78 0
Morbidity 12 553/897 0.67 0.53, 0.85 0.0009 0.05 0.44
Secondary outcomes        
Hepatic insufficiency 8 430/506 3.09 1.15, 8.31 0.03 0.001 0.71
Renal insufficiency 4 154/129 1.07 0.40, 2.84 0.89 0.33 0.13
Intraoperative transfusion 7 546/597 0.72 0.55, 0.94 0.02 0.07 0.49
Bile leak 6 236/433 0.58 1.24, 1.41 0.04 0.04 57%
R0 5 325/435 1.36 0.93, 1.96 0.11 0.77 0%
Infection 8 414/535 0.31 0.20, 0.47 < 0.001 0.16 16%
Cholangitis 3 111/160 0.18 0.007, 0.48 0.0007 0.15 48%
Intra-abdominal abscess 5 147/289 0.48 0.22, 1.32 0.07 0.94 0%
Intraoperative blood loss 5 315/412 32.34 − 375.83, 440.51 0.88 < 0.001 99%
Operative time 4 235/294 − 63.21 − 156.16, 29.73 0.18 < 0.001 90%
Secondary laparotomy 4 239/117 1.37 0.52, 3.63 0.53 0.47 0%
Anastomotic leakage 3 117/248 0.55 0.15, 2.10 0.38 0.64 0%
Abdominal collection 3 103/93 0.9 0.40, 2.00 0.79 0.82 0%
  1. The charts filled with gray means valid outcomes (P < 0.05)
  2. NPBD non-preoperative biliary drainage, PBD preoperative biliary drainage, No. of patients NPBD group/PBD group, OR odds ratio, WMD weighted mean difference, hCCAAA hilar cholangiocarcinoma