|
Outcome of interest
|
No. of studies
|
No. of patients
|
OR/WMD
|
95% CI
|
P value
|
Heterogeneity P value
|
I2
|
|---|
|
Primary outcomes
| | | | | | | |
|
Mortality
|
16
|
775/1085
|
0.91
|
0.64, 1.30
|
0.62
|
0.78
|
0
|
|
Morbidity
|
12
|
553/897
|
0.67
|
0.53, 0.85
|
0.0009
|
0.05
|
0.44
|
|
Secondary outcomes
| | | | | | | |
|
Hepatic insufficiency
|
8
|
430/506
|
3.09
|
1.15, 8.31
|
0.03
|
0.001
|
0.71
|
|
Renal insufficiency
|
4
|
154/129
|
1.07
|
0.40, 2.84
|
0.89
|
0.33
|
0.13
|
|
Intraoperative transfusion
|
7
|
546/597
|
0.72
|
0.55, 0.94
|
0.02
|
0.07
|
0.49
|
|
Bile leak
|
6
|
236/433
|
0.58
|
1.24, 1.41
|
0.04
|
0.04
|
57%
|
|
R0
|
5
|
325/435
|
1.36
|
0.93, 1.96
|
0.11
|
0.77
|
0%
|
|
Infection
|
8
|
414/535
|
0.31
|
0.20, 0.47
|
< 0.001
|
0.16
|
16%
|
|
Cholangitis
|
3
|
111/160
|
0.18
|
0.007, 0.48
|
0.0007
|
0.15
|
48%
|
|
Intra-abdominal abscess
|
5
|
147/289
|
0.48
|
0.22, 1.32
|
0.07
|
0.94
|
0%
|
|
Intraoperative blood loss
|
5
|
315/412
|
32.34
|
− 375.83, 440.51
|
0.88
|
< 0.001
|
99%
|
|
Operative time
|
4
|
235/294
|
− 63.21
|
− 156.16, 29.73
|
0.18
|
< 0.001
|
90%
|
|
Secondary laparotomy
|
4
|
239/117
|
1.37
|
0.52, 3.63
|
0.53
|
0.47
|
0%
|
|
Anastomotic leakage
|
3
|
117/248
|
0.55
|
0.15, 2.10
|
0.38
|
0.64
|
0%
|
|
Abdominal collection
|
3
|
103/93
|
0.9
|
0.40, 2.00
|
0.79
|
0.82
|
0%
|
- The charts filled with gray means valid outcomes (P < 0.05)
- NPBD non-preoperative biliary drainage, PBD preoperative biliary drainage, No. of patients NPBD group/PBD group, OR odds ratio, WMD weighted mean difference, hCCAAA hilar cholangiocarcinoma
