The effect and safety of preoperative biliary drainage in patients with hilar cholangiocarcinoma: an updated meta-analysis

Table 5 Results of meta-analysis comparing NPBD versus PBD for hCCA

Outcome of interest	No. of studies	No. of patients	OR/WMD	95% CI	P value	Heterogeneity P value	I²
Primary outcomes
Mortality	16	775/1085	0.91	0.64, 1.30	0.62	0.78	0
Morbidity	12	553/897	0.67	0.53, 0.85	0.0009	0.05	0.44
Secondary outcomes
Hepatic insufficiency	8	430/506	3.09	1.15, 8.31	0.03	0.001	0.71
Renal insufficiency	4	154/129	1.07	0.40, 2.84	0.89	0.33	0.13
Intraoperative transfusion	7	546/597	0.72	0.55, 0.94	0.02	0.07	0.49
Bile leak	6	236/433	0.58	1.24, 1.41	0.04	0.04	57%
R0	5	325/435	1.36	0.93, 1.96	0.11	0.77	0%
Infection	8	414/535	0.31	0.20, 0.47	< 0.001	0.16	16%
Cholangitis	3	111/160	0.18	0.007, 0.48	0.0007	0.15	48%
Intra-abdominal abscess	5	147/289	0.48	0.22, 1.32	0.07	0.94	0%
Intraoperative blood loss	5	315/412	32.34	− 375.83, 440.51	0.88	< 0.001	99%
Operative time	4	235/294	− 63.21	− 156.16, 29.73	0.18	< 0.001	90%
Secondary laparotomy	4	239/117	1.37	0.52, 3.63	0.53	0.47	0%
Anastomotic leakage	3	117/248	0.55	0.15, 2.10	0.38	0.64	0%
Abdominal collection	3	103/93	0.9	0.40, 2.00	0.79	0.82	0%

The charts filled with gray means valid outcomes (P < 0.05)
NPBD non-preoperative biliary drainage, PBD preoperative biliary drainage, No. of patients NPBD group/PBD group, OR odds ratio, WMD weighted mean difference, hCCAAA hilar cholangiocarcinoma

ISSN: 1477-7819