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Table 2 Characteristics of the studies included

From: The effect and safety of preoperative biliary drainage in patients with hilar cholangiocarcinoma: an updated meta-analysis

Author Country Year Design No of patients Age TSB(μmol/l) Sex (M/F) BMI Bismuth-classification
NPBD PBD NPBD PBD NPBD PBD NPBD PND NPBD PBD NPBD PBD
Cai et al. [21] CN 2017 RETRO 163 55 60 ± 9 59 ± 11 161.0 (8.4–455.6) 281.1 (8.2–565.4) 74/89 30/25 22.5 ± 6.8 21.8 ± 5.9 24/28/24/42/45 9/13/10/8/5
Kennedy et al. [22] USA 2009 RETRO 29 31 NR NR NR NR NR NR NR NR NR NR
Zhang et al. [23] CN 2017 RETRO 44 196 70 67 30.8 (15.4–99.2) 99.2 (39.3–205.2) 20/22 113/83 25.5 (23.7–28.7) 25.0 (22.3–28.7) 15 (I–II)/37 (III–IV) 49 (I–II)/130 (III–IV)
Xiong et al. [24] CN 2013 RETRO 46 32 58.2 ± 11.3 59.6 ± 11.0 254.0 ± 63.5 294.2 ± 135.7 28/18 21/11 21.0 ± 2.5 20.3±1.9 1/14/7/15/9 1/8/6/9/8
Farges et al. [25] EURO 2012 RETRO 186 180 62 ± 11 61 ± 10 126 (17–255) 113 (40–274) 107/79 127/53 24 ± 4 25 ± 4 6/47/267/19/27 4/23/137/10/6
Wronka et al. [26] Poland 2019 RETRO 23 58 56 (48–65) 60 (55–67) 164.8 (18.8–336.4) 36.6 (15.9–83.8) 13/10 34/24 NR NR NR NR
Ferrero et al. [27] Italy 2008 RETRO 30 30 63.5 (35–80) 66.0 (47–80) 210.3 (59.9–533.5) 225.7 19/11 13/17 NR NR NR NR
Su et al. [28] USA 1996 RETRO 16 33 NR NR NR NR NR NR NR NR NR NR
Li et al. [29] CN 2009 RETRO 56 55 NR NR 268 ± 174 256 ± 136 NR NR NR NR NR NR
Ribero et al. [30] Italy 2016 RETRO 35 98 67 (35–82) 65 (40–84) 94.1 63.3 22/13 62/36 NR NR 0/8/12/13/2 0/17/43/27/11
Parks et al. [31] UK 2000 RETRO 27 20 59 ± 3 57 ± 2 335 (9–670) 278 (35–666) 20/7 16/4 NR NR 2/7/11/5/2 2/2/10/2/4
Dinant et al. [32] Netherlands 2006 RETRO 14 83 NR NR NR NR NR NR NR NR NR NR
Hanafy [33] Egypt 2010 RETRO 54 46 50.4 ± 12 53.3±11 314.6 ± 205.2 92.34 ± 126.5 34/20 30/16 NR NR NR NR
Ercolani et al. [34] Japan 2010 RETRO 7 44 NR NR NR NR NR NR NR NR NR NR
Gerhards et al. [35] Netherlands 1999 RETRO 18 93 NR NR NR NR NR NR NR NR NR NR
Chen et al. [36] CN 2007 RETRO 27 31 NR NR 382 ± 174 292 ± 103 NR NR NR NR 2/6/3/7/9 1/4/6/12/8
  1. Data shown represents mean ± standard deviation or median (minimum-maximum); Bismuth-classification = I/II/IIIa/IIIb/
  2. TSB total serum bilirubin, No number, M male, F female, BMI body mass index, PBD preoperative biliary drainage group, NPBD non-preoperative biliary drainage group, Retro retrospective, NR not report