| Local recurrence | Distant metastasis | Overall survival | |||
---|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Univariate analyses | ||||||
 Age (≥ 65) | 0.891 (0.379–2.095) | 0.791 | 1.382 (0.845–2.260) | 0.197 | 1.598 (0.964–2.651) | 0.069 |
 Sex (male) | 0.790 (0.342–1.823) | 0.581 | 0.992 (0.630–1.565) | 0.974 | 0.767 (0.483–1.219) | 0.262 |
 Tumor location (head) | 1.247 (0.532–2.924) | 0.612 | 1.567 (0.980–2.507) | 0.061 | 1.564 (0.972–2.519) | 0.066 |
 Tumor size (pT3/pT4) | 1.937 (0.646–5.808) | 0.238 | 1.213 (0.601–2.448) | 0.591 | 1.959 (1.037–3.698) | 0.038 |
 Differentiation grade (G3/G4) | 3.130 (1.133–8.651) | 0.028 | 2.330 (1.186–4.577) | 0.014 | 2.710 (1.423–5.162) | 0.002 |
 Differentiation grade (G2/G3/G4) | 1.854 (0.773–4.448) | 0.167 | 1.750 (1.098–2.790) | 0.019 | 1.717 (1.066- 2.764) | 0.026 |
 Microvenous invasion (yes) | 3.136 (0.422–23.334) | 0.264 | 2.014 (0.874–4.640) | 0.100 | 1.471 (0.672–3.223) | 0.334 |
 Lymphatic permeation (yes) | 1.278 (0.472–3.466) | 0.629 | 2.273 (1.224–4.224) | 0.009 | 1.911 (1.026–3.558) | 0.041 |
 Perineural invasion (yes) | 4.169 (0.560–31.015) | 0.163 | 1.060 (0.559–2.012) | 0.858 | 1.136 (0.582–2.219) | 0.708 |
 Resection margin (R1) | 1.396 (0.595–3.273) | 0.443 | 1.048 (0.651–1.687) | 0.846 | 1.188 (0.738–1.912) | 0.479 |
 Nodal metastasis (yes) | 1.024 (0.437–2.399) | 0.956 | 2.082 (1.262–3.433) | 0.004 | 1.574 (0.967–2.563) | 0.068 |
 TNM stage (III/IV) | 1.007 (0.340–2.980) | 0.990 | n.d. | n.d. | 1.768 (1.035–3.018) | 0.037 |
 Neoadjuvant chemotherapy (yes) | 1.196 (0.516–2.772) | 0.677 | 0.865 (0.550–1.361) | 0.531 | 0.981 (0.617–1.560) | 0.935 |
 Adjuvant chemotherapy (yes) | 0.867 (0.202- 3.728) | 0.848 | 0.872 (0.377–2.015) | 0.748 | 0.622 (0.284–1.364) | 0.236 |
 Postoperative radiotherapy (yes) | 1.339 (0.313–5.739) | 0.694 | 0.780 (0.314–1.941) | 0.593 | 0.758 (0.305–1.884) | 0.551 |
Multivariate analyses | ||||||
 Age (≥ 65) | n.d. | n.d. | n.d. | n.d. | 1.481 (0.875–2.506) | 0.143 |
 Tumor location (head) | n.d. | n.d. | 1.253 (0.770–2.039) | 0.364 | 1.621 (0.988–2.661) | 0.056 |
 Tumor size (pT3/pT4) | n.d. | n.d. | n.d. | n.d. | 1.586 (0.805–3.124) | 0.182 |
 Differentiation grade (G3/G4) | n.d. | n.d. | 2.705 (1.353–5.408) | 0.005 | 2.372 (1.228–4.582) | 0.010 |
 Nodal metastasis (yes) | n.d. | n.d. | 2.125 (1.258–3.590) | 0.005 | 1.260 (0.757–2.099) | 0.374 |
 Age (≥ 65) | n.d. | n.d. | n.d. | n.d. | 1.603 (0.940–2.736) | 0.083 |
 Tumor location (head) | n.d. | n.d. | 1.320 (0.809–2.155) | 0.267 | 1.710 (1.033–2.832) | 0.037 |
 Tumor size (pT3/pT4) | n.d. | n.d. | n.d. | n.d. | 1.902 (0.974–3.717) | 0.060 |
 Differentiation grade (G2/G3/G4) | n.d. | n.d. | 1.687 (1.057–2.692) | 0.028 | 1.780 (1.091–2.905) | 0.021 |
 Nodal metastasis (yes) | n.d. | n.d. | 1.857 (1.101–3.132) | 0.020 | 1.140 (0.678–1.918) | 0.621 |