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Table 2 Clinicopathologic features of patients with normal mucosa or PanIN-1 and those with PanIN-2 or PanIN-3 at the PTM

From: Clinical impacts of resection margin status and clinicopathologic parameters on pancreatic ductal adenocarcinoma

ParametersNormal mucosa and PanIN-1 (n = 57)PanIN-2 and PanIN-3 (n = 21)P value
Median age (range)69 (45–85)69 (56–90)0.257
Sex
 Male3170.128
 Female2614
Tumor location
 Head33150.308
 Body and tail246
Differentiation grade of PDAC
 G1/G250191.000
 G3/G472
Differentiation grade of PDAC
 G126110.619
 G2/G3/G43110
TNM stage
 I/II49181.000
 III/IV83
Tumor size
 pT1/pT250200.437
 pT3/pT471
Microvascular invasion
 Positive52180.383
 Negative43
 Unknown1  
Lymphatic permeation
 Positive39151.000
 Negative186
Perineural invasion
 Positive47150.346
 Negative106
Nodal metastasis
 pN02290.797
 pN1/pN23512
Neoadjuvant chemotherapy
 Yes3690.127
 No2112
Adjuvant chemotherapy
 Yes50191.000
 No51
 Unknown21 
Postoperative radiotherapy
 Yes220.292
 No5519
  1. Patients with invasive cancer at any resection margins other than the PTM are excluded. PanIN pancreatic intraepithelial neoplasia, PTM pancreatic transection margin, PDAC pancreatic ductal adenocarcinoma, G1 well-differentiated carcinoma, G2 moderately differentiated carcinoma, G3 poorly differentiated carcinoma, G4 undifferentiated carcinoma