| Epidemiology | | | | |
| Sex, male | 0.42 | | 0.26 | |
| HBs-Ag positive | 0.72 | | 0.13 | |
| HCV-Ab positive | 0.18 | | 0.80 | |
| NBNC | 0.38 | | 0.13 | |
| Biochemical factors | | | | |
| Platelets < 100,000/mm3 | 0.84 | | 0.34 | |
| PA < 80% | 0.03 | 0.27 (1.261) (0.833–1.908) | < 0.01 | 0.01 (1.449) (1.063–1.974) |
| ChE < 180 IU/l | < 0.01 | 0.13 (1.416) (0.901–2.225) | < 0.01 | 0.79 (0.954) (0.666–1.366) |
| Albumin < 3.5 g/dl | < 0.01 | 0.47 (1.215) (0.711–2.076) | < 0.01 | < 0.01 (1.834) (1.213–2.774) |
| ICGR15 ≥ 15% | 0.94 | | 0.09 | |
| AFP ≥ 20 ng/ml | < 0.01 | < 0.01 (1.769) (1.242–2.520) | < 0.01 | 0.02 (1.344) (1.029–1.755) |
| PIVKA-II ≥ 400 mAU/ml | < 0.01 | 0.83 (1.045) (0.691–1.580) | < 0.01 | 0.88 (0.977) (0.715–1.333) |
| Tumor factors | | | | |
| Tumor size ≥ 10 cm | < 0.01 | 0.78 (0.932) (0.570–1.526) | < 0.01 | 0.01 (1.637) (1.122–2.388) |
| Tumor number multiple | < 0.01 | < 0.01 (1.674) (1.194–2.346) | < 0.01 | < 0.01 (1.704) (1.307–2.222) |
| Macroscopic type except simple nodular | < 0.01 | 0.52 (0.880) (0.593–1.306) | < 0.01 | 0.72 (0.947) (0.704–1.274) |
| Histological factors | | | | |
| Differentiation, poor | < 0.01 | < 0.01 (1.818) (1.270–2.601) | < 0.01 | 0.01 (1.419) (1.070–1.884) |
| PVI | < 0.01 | < 0.01 (1.904) (1.290–2.808) | < 0.01 | 0.02 (1.467) (1.061–2.028) |
| HVI | < 0.01 | 0.02 (1.718) (1.080–2.735) | < 0.01 | 0.66 (1.089) (0.734–1.615) |
| Fibrosis | 0.18 | | 0.05 | |
| Surgical factors | | | | |
| FRLR ≥ 50% | 0.42 | | 0.49 | |
| Non-anatomical resection | 0.79 | | 0.89 | |
| Blood loss ≥ 400 ml | < 0.01 | 0.01 (1.604) (1.108–2.323) | < 0.01 | 0.15 (1.218) (0.927–1.601) |
