| Overall survival | Relapse-free survival | ||
---|---|---|---|---|
Characteristics | Univariate (p) | Multivariate (p) (hazard ratio) (95% CI) | Univariate (p) | Multivariate (p) (hazard ratio) (95% CI) |
Epidemiology | Â | Â | Â | Â |
 Sex, male | 0.42 |  | 0.26 |  |
 HBs-Ag positive | 0.72 |  | 0.13 |  |
 HCV-Ab positive | 0.18 |  | 0.80 |  |
 NBNC | 0.38 |  | 0.13 |  |
Biochemical factors | Â | Â | Â | Â |
 Platelets < 100,000/mm3 | 0.84 |  | 0.34 |  |
 PA < 80% | 0.03 | 0.27 (1.261) (0.833–1.908) | < 0.01 | 0.01 (1.449) (1.063–1.974) |
 ChE < 180 IU/l | < 0.01 | 0.13 (1.416) (0.901–2.225) | < 0.01 | 0.79 (0.954) (0.666–1.366) |
 Albumin < 3.5 g/dl | < 0.01 | 0.47 (1.215) (0.711–2.076) | < 0.01 | < 0.01 (1.834) (1.213–2.774) |
 ICGR15 ≥ 15% | 0.94 |  | 0.09 |  |
 AFP ≥ 20 ng/ml | < 0.01 | < 0.01 (1.769) (1.242–2.520) | < 0.01 | 0.02 (1.344) (1.029–1.755) |
 PIVKA-II ≥ 400 mAU/ml | < 0.01 | 0.83 (1.045) (0.691–1.580) | < 0.01 | 0.88 (0.977) (0.715–1.333) |
Tumor factors | Â | Â | Â | Â |
 Tumor size ≥ 10 cm | < 0.01 | 0.78 (0.932) (0.570–1.526) | < 0.01 | 0.01 (1.637) (1.122–2.388) |
 Tumor number multiple | < 0.01 | < 0.01 (1.674) (1.194–2.346) | < 0.01 | < 0.01 (1.704) (1.307–2.222) |
 Macroscopic type except simple nodular | < 0.01 | 0.52 (0.880) (0.593–1.306) | < 0.01 | 0.72 (0.947) (0.704–1.274) |
Histological factors | Â | Â | Â | Â |
 Differentiation, poor | < 0.01 | < 0.01 (1.818) (1.270–2.601) | < 0.01 | 0.01 (1.419) (1.070–1.884) |
 PVI | < 0.01 | < 0.01 (1.904) (1.290–2.808) | < 0.01 | 0.02 (1.467) (1.061–2.028) |
 HVI | < 0.01 | 0.02 (1.718) (1.080–2.735) | < 0.01 | 0.66 (1.089) (0.734–1.615) |
 Fibrosis | 0.18 |  | 0.05 |  |
Surgical factors | Â | Â | Â | Â |
 FRLR ≥ 50% | 0.42 |  | 0.49 |  |
 Non-anatomical resection | 0.79 |  | 0.89 |  |
 Blood loss ≥ 400 ml | < 0.01 | 0.01 (1.604) (1.108–2.323) | < 0.01 | 0.15 (1.218) (0.927–1.601) |