Skip to main content

Table 6 Prognostic factors for survival and recurrence of young patients

From: Prognoses, outcomes, and clinicopathological characteristics of very elderly patients with hepatocellular carcinoma who underwent hepatectomy

 

Overall survival

Relapse-free survival

Characteristics

Univariate (p)

Multivariate (p) (hazard ratio) (95% CI)

Univariate (p)

Multivariate (p) (hazard ratio) (95% CI)

Epidemiology

    

 Sex, male

0.42

 

0.26

 

 HBs-Ag positive

0.72

 

0.13

 

 HCV-Ab positive

0.18

 

0.80

 

 NBNC

0.38

 

0.13

 

Biochemical factors

    

 Platelets < 100,000/mm3

0.84

 

0.34

 

 PA < 80%

0.03

0.27 (1.261) (0.833–1.908)

< 0.01

0.01 (1.449) (1.063–1.974)

 ChE < 180 IU/l

< 0.01

0.13 (1.416) (0.901–2.225)

< 0.01

0.79 (0.954) (0.666–1.366)

 Albumin < 3.5 g/dl

< 0.01

0.47 (1.215) (0.711–2.076)

< 0.01

< 0.01 (1.834) (1.213–2.774)

 ICGR15 ≥ 15%

0.94

 

0.09

 

 AFP ≥ 20 ng/ml

< 0.01

< 0.01 (1.769) (1.242–2.520)

< 0.01

0.02 (1.344) (1.029–1.755)

 PIVKA-II ≥ 400 mAU/ml

< 0.01

0.83 (1.045) (0.691–1.580)

< 0.01

0.88 (0.977) (0.715–1.333)

Tumor factors

    

 Tumor size ≥ 10 cm

< 0.01

0.78 (0.932) (0.570–1.526)

< 0.01

0.01 (1.637) (1.122–2.388)

 Tumor number multiple

< 0.01

< 0.01 (1.674) (1.194–2.346)

< 0.01

< 0.01 (1.704) (1.307–2.222)

 Macroscopic type except simple nodular

< 0.01

0.52 (0.880) (0.593–1.306)

< 0.01

0.72 (0.947) (0.704–1.274)

Histological factors

    

 Differentiation, poor

< 0.01

< 0.01 (1.818) (1.270–2.601)

< 0.01

0.01 (1.419) (1.070–1.884)

 PVI

< 0.01

< 0.01 (1.904) (1.290–2.808)

< 0.01

0.02 (1.467) (1.061–2.028)

 HVI

< 0.01

0.02 (1.718) (1.080–2.735)

< 0.01

0.66 (1.089) (0.734–1.615)

 Fibrosis

0.18

 

0.05

 

Surgical factors

    

 FRLR ≥ 50%

0.42

 

0.49

 

 Non-anatomical resection

0.79

 

0.89

 

 Blood loss ≥ 400 ml

< 0.01

0.01 (1.604) (1.108–2.323)

< 0.01

0.15 (1.218) (0.927–1.601)

  1. PA prothrombin activity, ChE cholinesterase, ICGR15 indocyanine green retention rate at 15 min, AFP alpha-fetoprotein, PIVKA-II protein induced by vitamin K absence-II, PVI portal venous invasion, HVI hepatic venous invasion, FRLR future remnant liver rates