Table 1 Clinicopathological characteristics of HCC

Epidemiology

 Age (years old)

82 (80–92)

71 (65–79)

57 (33–64)

< 0.01

< 0.01

 Sex, male to female (%)

80(39):20(10)

83(301):17(62)

84(321):16(63)

0.56

0.48

 HBs-Ag positive (%)

6 (3)

19 (69)

53 (205)

0.02

< 0.01

 HCV-Ab positive (%)

35 (17)

34 (122)

21 (80)

0.88

0.02

 Both HBs-Ag and HCV-Ab positive (%)

0 (0)

1 (5)

3 (10)

0.40

0.25

 NBNC (%)

59 (29)

46 (167)

23 (89)

0.08

< 0.01

Biochemical factors

 Child-Pugh score

5.2 ± 0.5

5.2 ± 0.5

5.2 ± 0.5

0.50

0.38

 Platelets (10⁴/mm³)

18.4 ± 6.8

17.5 ± 10.8

17.0 ± 7.6

0.54

0.20

 PA (%)

94.8 ± 13.5

92.5 ± 14.0

91.4 ± 13.9

0.28

0.10

 ChE (IU/l)

230 ± 68

244 ± 71

262 ± 90

0.22

0.01

 Albumin (g/dl)

3.9 ± 0.3

4.0 ± 0.4

4.1 ± 0.5

0.06

0.04

 ICGR15 (%)

15.8 ± 8.2

16.7 ± 9.6

15.8 ± 11.5

0.56

0.94

 AFP (ng/ml)

5.5 (0–60,961)

10.6 (0–378,718)

27.5 (1–5,986,980)

0.05

< 0.01

 PIVKA-II (mAU/ml)

198 (10–217,422)

181 (8–664,680)

207 (2.3–928,799)

0.95

0.98

Tumor factors

 Tumor size (cm)

6.4 ± 3.5

5.7 ± 4.1

6.1 ± 5.2

0.23

0.66

 Multiple tumor (%)

31 (15)

35 (128)

38 (144)

0.52

0.34

 Differentiation, poor (%)

39 (19)

37 (134)

46 (175)

0.80

0.36

 PVI (%)

14 (7)

21 (75)

34 (131)

0.29

< 0.01

 HVI (%)

14 (7)

11 (41)

14 (52)

0.54

0.88

 Fibrosis, f3/f4 (%)

16 (8)

40 (146)

55 (213)

< 0.01

< 0.01