Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia

Table 2 Odds ratios and confidence intervals for advanced stages at diagnosis in 1059 breast cancer patients

Variable	Category	Stage		Univariable analysis		Multivariable analysis
		Stage		OR (95% CI)	P value	OR (95% CI)	P value
		Advance (n)	Early (n)	OR (95% CI)	P value	OR (95% CI)	P value
Age	≤ 40 years old	116	69	1.230 (0.884–1.709)	0.220	0.868 (0.544–1.384)	0.551
Age	> 40 years old	589	285	Ref		Ref
Breastfeeding	Yes	566	281	0.945 (0.688-1.298)	0.745	0.897 (0.556-1.445)	0.654
Breastfeeding	No	139	73	Ref		Ref
Marital status	Not married	43	19	Ref		Ref
Marital status	Married	662	335	0.873 (0.501–1.522)	0.625	0.858 (0.473–1.557)	0.614
Education	Lower than high school	339	102	2.288 (1.741–3.008)	< 0.0001	1.533 (1.132–2.075)	0.006
Education	High school and graduate	366	252	Ref		Ref
Parity	Nulliparity	75	42	0.884 (0.592–1.321)	0.559	0.923 (0.505–1.668)	0.779
Parity	Multiparity	630	312	Ref		Ref
Ethnicity	Javanese	690	347	0.928 (0.375–2.297)	0.998	0.506 (0.190–1.350)	0.174
Ethnicity	Non-Javanese	15	7	Ref		Ref
BMI	≤ 25	450	212	1.182 (0.909–1.536)	0.211	1.060 (0.794–1.416)	0.693
BMI	> 25	255	142	Ref		Ref	Ref
Menarche	≤ 14 years old	456	237	Ref		Ref	Ref
Menarche	> 14 years old	249	117	1.106 (0.844–1.449)	0.464	1.058 (0.788–1.420)	0.631
Menopause	≤ 50 years old	397	185	1.164 (0.820–1.653)	0.396	1.120 (0.855–1.468)	0.409
Menopause	> 50 years old	118	64	Ref		Ref	Ref
Family history	Yes	126	70	0.883 (0.638–1.222)	0.465	0.877 (0.623–1.246)	0.508
Family history	No	579	284	Ref		Ref
Residence	Rural	586	166	5.577 (4.185–7.431)	< 0.0001	5.096 (3.765–6.896)	< 0.0001
Residence	Urban	119	188	Ref		Ref

Association of sociodemographic variables with advance stages at diagnosis were analyzed using univariable and multivariable binary logistic regression
Ref reference, OR odd ratio, CI confidence interval, BMI body mass index

ISSN: 1477-7819