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Table 1 Characteristics of included studies

From: Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis

Author, year, country

Patients (n)

Age (year) (range and mean)

Invasive cancer/DCIS

Contrast agent

Injection site

Imaging system

Localization method

Comparator

Maryam, 2015, Iran

50

23–69

50/0

DEFINITY

Peritumoral parenchyma

Not explained

Guidewire

Blue dye + radio-isotope

Zhou, 2017, China

46

35–66

46/0

SonoVue

Periareolar intradermal and peritumoral parenchyma approaching the axilla

MyLab, Twice scanner, A high- frequency linear-array probe (LA522)

Titanium clip

Blue dye

Li, 2019, China

453

28–72

453/0

SonoVue

Periareolar intradermal

Philips, iU 22 ultrasound system

Skin marked

Blue dye

Kenzo, 2017, Japan

100

 

94/6

Sonazoid

Periareolar intradermal and subdermal

GE Logiq E9 with XDclear

FNA

Blue dye + radio-isotope

Tomohiro,2019,Japan

50

 

50/0

Sonazoid

Periareolar intradermal and subdermal

Aplio i700®

Guidewire

Blue dye or ICG

Xie, 2015, China

101

22–82

101/0

SonoVue

periareolar intradermal

GE Logiq E9 scanners

Guidewire

Blue dye

Sever, 2011, UK

80 (2 male)

32–82

78/2

SonoVue

Periareolar intradermal

Acuson Sequoia 512 scanner

Guidewire

Blue dye + radio-isotope

Kenzo, 2019, Japan

75

Not explained

66/9

Sonazoid

Periareolar intradermal and subdermal

GE Logiq E9 with XDclear

Skin marked and FNA and 54 US-guided dye marking use ICG

Blue dye + ICG

Zhao, 2017, China

110 (1 male)

28–76

95/15

SonoVue

Periareolar intradermal

Acuson S2000

Skin marked

Blue dye

Zhong, 2018, China

126 (1 male)

Not explained

110/16

SonoVue

Periareolar intradermal

MyLab Twice system

FNA + skin marked

Blue dye + radio-isotope

Liu, 2019, China

75 (1 male)

31–71 (49.3)

66/9

SonoVue

Periareolar intradermal

PhilipsEPIC Q7

Skin marked

Blue dye

Omoto, 2009, Japan

20

32–78 (50.9)

16/4

Sonazoid

Subareolar

GE LOGIQ7 BT07

Skin marked

Blue dye, radio-isotope

Omoto, 2011, Japan, abstract

181

Not explain

Not explained

Sonazoid

Subareolar

Not explained

Skin marked

Blue dye, radio-isotope

Cheng, 2014, China, abstract

80

Not explain

Not explained

SonoVue

Periareolar intradermal

Not explained

Guide wire

Blue dye

Matsuzawa, 2015, Japan

32

32–86 (60.4)

26/6

Sonazoid

Subareolar

Aplio500

Skin marked

Blue dye

Barentsz, 2015, Netherlands

14 (1 bilateral)

41–68 (56.0)

14/1

SonoVue

Periareolar intradermal and subdermal

Philips iU22 scanner

Placed I-125 seed

Blue dye, radio-isotope

  1. FNA fine needle aspiration, ICG indocyanine green