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Table 3 Characteristics of included studies

From: Laparoscopic versus open approach in gastrectomy for advanced gastric cancer: a systematic review

References Year Country Study design Study period Male/female Age Tumor size BMI ASA (1:2:3)
L O L O L O L O
Huang et al. [14] 2010 Chi- Cohort 2007–2008 40/26 39/30 55.80 ± 9.21 56.37 ± 10.63 -
Cai et al [15] 2011 Chi- RCT 2008–2009 39/10 37/10 54.4 ± 10.6 52.6 ± 13.6 4.15 ± 2.03 4.32 ± 1.78 21.99 ± 3.29 22.87 ± 2.76
Scatizzi et al. [16] 2011 Italy CCS 2006–2009 14/16 16/14 70 ± 12 69 ± 10.75 5.6 ± 3 7.2 ± 2.25 22 ± 1 24 ± 6.5 8/25/17
Shuang et al [17] 2011 Chi- CCS 2005–2007 30/5 30/5 58 ± 10.5 59 ± 16 21 ± 3 23 ± 3
Zhao et al. [18] 2011 Chi- CCS 2004–2009 248/98 221/92 51.43 ± 11.45 52.57 ± 12.37 4.4 ± 1.57 4.6 ± 1.72
Chun et al. [20] 2012 Korea CCS 2004–2009 30/22 48/19 61.1 ± 12.6 60.8 ± 11.1 3.4 ± 1.6 4.0 ± 2.1 22.8 ± 2.8 22.9 ± 3.0
Hamabe et al. [21] 2012 Japan Cohort 2000–2009 47/19 70/31 66.3 64.2 3.54 4.05
Kim et al. [22] 2012 Korea CCS 2006–2007 53/35 50/38 56.0 ± 13.5 59.0 ± 13.1 3.8 ± 2.2 5.2 ± 2.7 22.9 ± 3.0 22.5 ± 3.0
Moisan et al. [23] 2012 Chile Cohort 2003–2010 21/10 20/11 67 ± 13.5 67 ± 14 3.7 ± 1.975 4.5 ± 2.425 26 ± 2.75 25.5 ± 3.5 22/38/2
Bo et al. [24] 2013 Chi- CCS 2004–2010 82/35 80/37 54.5 ± 10.6 52.6 ± 13.6 21.1 ± 3.0 21.7 ± 3.8
Gordon et al. [25] 2012 Japan CCS 1999–2010 18/48 39/93 63.95 ± 12.11 66.96 ± 11.86 22.84 ± 3.45 22.06 ± 3.33
Lin et al. [26] 2013 Chi- Cohort 2008–2010 12/71 12/71 61.6 ± 10.3 61.1 ± 10.5 4.6 ± 2.1 4.4 ± 2.2 22.3 21.5
Shinohara et al. [27] 2012 Japan Cohort 1998–2008 129/57 85/38 61.4 ± 11.7 63.1 ± 9.9 21.5 ± 3.2 21.4 ± 3.3 173/127/9
Fang et al. [28] 2014 Chi- CCS 2005–2009 78/9 78/9 57 ± 8.16 56 ± 7.66 4.4 ± 1.90 4.8 ± 1.50 23.3 ± 2.216 22.9 ± 2.216 69/81/24
Qiu et al. [29] 2014 Chi- CCS 2012–2013 25/5 22/12 74.4 ± 3.1 75.6 ± 3.0 4.1 ± 1.9 4.9 ± 2.6 21.6 ± 2.7 21.6 ± 3.0 2/45/17
Cui et al. [30] 2015 Chi- RCT 2010–2012 88/40 98/44 60.1 ± 12.6 57.5 ± 11.2 23.03 ± 3.61 23.66 ± 3.23
Wu et al. [31] 2015 Chi- CCS 2010–2012 92/68 115/80 58.09 ± 10.87 58.61 ± 12.33 22.40 ± 3.85 22.20 ± 3.75
Zhang et al. [32] 2015 Chi- CCS 2007–2014 57/29 61/25 62 ± 4.83 61 ± 4.00 107/49/16
Hao et al. [33] 2016 Chi- CCS 2004–2011 437/191 414/165 54.57 ± 14.46 55.66 ± 12.59 610/520/77
Hu et al. [34] 2016 Chi- RCT 2012–2014 380/129 346/174 56.5 ± 10.4 55.8 ± 11.1 4.0 ± 2.0 4.0 ± 2.1 22.7 ± 3.2 22.7 ± 3.2
Li1 et al. [35] 2016 Chi- CCS 2012–2014 54/47 53/48 57.7 ± 10.5 59.5 ± 10.1 23.7 ± 71.1 23.7 ± 1.0 57/106/39
Li2 et al. [35] 2016 Chi- RCT 2012–2014 13/7 27/3 53.5 ± 9.2 56.0 ± 9.2 3.7 ± 1.9 2.5 ± 1.3 22.4 ± 3.7 23.0 ± 3.1 1/38/5
Lu et al. [37] 2016 Chi- CCS 2008–2015 39/22 37/24 59 ± 7.75 57 ± 6.75 19 ± 1.25 22 ± 2 88/26/8
Zhang et al. [38] 2016 Chi- CCS 2009–2014 65/27 59/33 63 ± 5.66 65 ± 5.66 19 ± 1.66 22 ± 1.33 120/47/17
Xu1 et al. [39] 2017 Chi- CCS 2007–2011 60/7 60/7 58.5 ± 10.5 57.7 ± 9.6 5.4 ± 2.3 5.8 ± 2.2 22.5 ± 3.2 22.6 ± 3.5 5/105/24
Zhang et al. [40] 2017 Chi- Cohort 2006–2008 63/48 69/50 57.2 ± 11.2 58.7 ± 12.1
Inokuchi et al. [41] 2018 Japan CCS 2001–2012 39/13 37/15 67 ± 10.25 68 ± 13 21.9 ± 3.65 22.1 ± 3.175 39/52/13
Li3 et al. [42] 2018 Chi- Cohort 2007–2012 322/88 311/99
Park et al. [43] 2018 Korea RCT 2010–2011 69/31 65/31 58.6 60.1 23.7 ± 3.0 23.3 ± 3.1
Shi et al. [44] 2018 Chi- RCT 2010–2012 120/42 105/55 55.23 ± 11.01 55.02 ± 10.79 4.28 ± 1.94 4.40 ± 1.97 20.7 ± 3.086 20.2 ± 2.948 161/128/33
Xu2 et al. [49] 2018 Chi- Cohort 2005–2012 342/88 595/173 55.6 ± 10.4 56.8 ± 10.6 4.7 ± 1.8 4.9 ± 1.8 22.4 ± 3.0 22.2 ± 3.2 165/873/157
Chan et al. [45] 2019 Hong Kong Cohort 2009–2017 35/19 110/57 70 ± 12.5 66 ± 9.5 13/136/71
Chen et al. [19] 2012 Chi- CCS 2008–2010 49/175 23/89 61.6 ± 10.6 60.8 ± 10.2 4.7 ± 2.0 4.4 ± 2.0 22.3 22 180/143/13
Kinoshita et al. [46] 2019 Japan Cohort 2008–2014 214/91 217/88 67.1 67.7 21.5 ± 3.1 21.6 ± 3.4 195/359/56
Lee et al. [47] 2019 Korea RCT 2011–2015 333/127 321/137 59.9 ± 10.8 59.5 ± 11.6 4.5 ± 2.4 4.5 ± 2.2 23.5 ± 2.9 23.7 ± 2.3 445/431/42
Wang et al. [48] 2019 Chi- RCT 2014–2017 144/78 133/87 59.4 ± 12.6 60.6 ± 10.2 3.6 ± 1.8 3.9 ± 1.2 23.1 ± 3.1 23.5 ± 3.5 179/255/8
  1. RCT randomized controlled trial, CCS case-controlled study, L laparoscopic gastrectomy, O open gastrectomy, TG total gastrectomy, DG distal gastrectomy, PG proximal gastrectomy, not available