From: The efficacy of surgery in advanced hepatocellular carcinoma: a cohort study
Characteristics | Multivariate analysis | |||
---|---|---|---|---|
Overall survival, HR (95% CI) | P value | Cancer-specific survival, HR (95% CI) | P value | |
Gender | ||||
Male | Reference | Reference | ||
Female | 1.121 (0.890, 1.411) | 0.332 | 0.912 (0.696, 1.194) | 0.501 |
Age at diagnosis | ||||
30–44 | Reference | Reference | ||
45–59 | 2.384 (1.369, 4.153) | 0.002 | 2.874 (1.539, 5.365) | 0.001 |
60–74 | 2.397 (1.382, 4.158) | 0.002 | 3.055 (1.645, 5.674) | < 0.001 |
75–84 | 2.631 (1.456, 4.757) | 0.001 | 3.059 (1.562, 5.993) | 0.001 |
Ethnicity | ||||
White | Reference | Reference | ||
Black | 0.913 (0.706, 1.181) | 0.490 | 0.844 (0.634, 1.121) | 0.844 |
Others | 0.8886 (0.675, 1.162) | 0.380 | 0.959 (0.709, 1.296) | 0.959 |
Marital status | ||||
Married | Reference | Reference | ||
Single | 0.968 (0.800, 1.172) | 0.741 | 1.026 (0.832, 1.264) | 0.812 |
Others | 1.323 (0.792, 2.209) | 0.285 | 1.429 (0.837, 2.442) | 0.191 |
AJCC T stage | ||||
T1 | Reference | Reference | ||
T2 | 1.324 (1.044, 1.679) | 0.021 | 1.381 (1.054, 1.811) | 0.019 |
T3 | 1.316 (1.024, 1.691) | 0.032 | 1.359 (1.031, 1.790) | 0.030 |
T4 | 1.766 (1.028, 3.034) | 0.039 | 1.682 (0.941, 3.008) | 0.079 |
TX | 1.462 (0.588, 3.633) | 0.413 | 1.322 (0.478, 3.661) | 0.591 |
Year of diagnosis | ||||
2004–2006 | Reference | Reference | ||
2007–2009 | 0.903 (0.711, 1.147) | 0.219 | 0.852 (0.655, 1.108) | 0.232 |
2010–2012 | 1.027 (0.798, 1.322) | 0.834 | 0.932 (0.701, 1.239) | 0.627 |
2013–2015 | 0.976 (0.748, 1.274) | 0.858 | 0.886 (0.659, 1.192) | 0.423 |
Tumor size | ||||
≤ 3 cm | Reference | Reference | ||
3–5 cm | 1.355 (1.040, 1.767) | 0.025 | 1.556 (1.149, 2.107) | 0.004 |
> 5 cm | 1.940 (1.462, 2.575) | < 0.001 | 2.173 (1.557, 3.032) | < 0.001 |
Tumor number | ||||
1 | Reference | Reference | ||
2 | 0.746 (0.538, 1.035) | 0.499 | 0.927 (0.450, 1.906) | 0.927 |
3 | 0.307 (0.125, 0.754) | 0.010 | N | 0.923 |
> 3 | 1.546 (0.483, 4.954) | 0.463 | N | N |
Radiotherapy | ||||
Yes | Reference | Reference | ||
No | 1.765 (1.194, 2.607) | 0.004 | 1.931 (1.262, 2.953) | 0.002 |
Chemotherapy | ||||
Yes | Reference | Reference | ||
No | 1.660 (1.383, 1.991) | < 0.001 | 1.852 (1.510, 2.271) | < 0.001 |
Surgery | ||||
Yes | Reference | Reference | ||
No | 2.150 (1.750, 2.641) | < 0.001 | 2.213 (1.760, 2.781) | < 0.001 |