From: The efficacy of surgery in advanced hepatocellular carcinoma: a cohort study
Characteristics | Multivariate analysis | |||
---|---|---|---|---|
Overall survival, HR (95% CI) | P value | Cancer-specific survival, HR (95% CI) | P value | |
Gender | ||||
Male | Reference | Reference | ||
Female | 1.104 (0.950, 1.282) | 0.196 | 0.982 (0.826, 1.167) | 0.833 |
Age at diagnosis | ||||
30–44 | Reference | Reference | ||
45–59 | 1.493 (1.025, 2.173) | 0.037 | 1.725 (1.132, 2.627) | 0.011 |
60–74 | 1.487 (1.023, 2.162) | 0.038 | 1.768 (1.160, 2.692) | 0.008 |
75–84 | 1.586 (1.068, 2.357) | 0.022 | 1.842 (1.176, 2.884) | 0.008 |
Ethnicity | ||||
White | Reference | Reference | ||
Black | 0.955 (0.823, 1.109) | 0.548 | 0.914 (0.772, 1.084) | 0.302 |
Others | 0.914 (0.773, 1.082) | 0.914 | 0.946 (0.788, 1.136) | 0.551 |
Marital status | ||||
Married | Reference | Reference | ||
Single | 1.010 (0.898, 1.135) | 0.869 | 1.040 (0.913, 1.186) | 0.554 |
Others | 0.988 (0.749, 1.303) | 0.931 | 1.066 (0.793, 1.433) | 0.674 |
AJCC T stage | ||||
T1 | Reference | Reference | ||
T2 | 1.165 (0.980, 1.385) | 0.084 | 1.230 (1.09, 1.500) | 0.040 |
T3 | 1.418 (1.217, 1.652) | < 0.001 | 1.412 (1.189, 1.677) | < 0.001 |
T4 | 1.703 (1.294, 2.240) | < 0.001 | 1.881 (1.398, 2.529) | < 0.001 |
TX | 1.443 (0.868, 2.400) | 0.157 | 1.343 (0.729, 2.474) | 0.344 |
Year of diagnosis | ||||
2004–2006 | Reference | Reference | ||
2007–2009 | 0.948 (0.791, 1.137) | 0.564 | 0.973 (0.794, 1.191) | 0.789 |
2010–2012 | 1.197 (1.009, 1.421) | 0.039 | 1.175 (0.970, 1.424) | 0.100 |
2013–2015 | 1.109 (0.930, 1.322) | 0.251 | 1.070 (0.878, 1.303) | 0.503 |
Tumor size | ||||
≤ 3 cm | Reference | Reference | ||
3–5 cm | 1.305 (1.080, 1.577) | 0.006 | 1.432 (1.151, 1.781) | 0.001 |
>5 cm | 1.685 (1.392, 2.039) | < 0.001 | 1.857 (1.487, 2.318) | < 0.001 |
Tumor number | ||||
1 | Reference | Reference | ||
2 | 0.872 (0.727, 1.046) | 0.141 | 0.740 (0.461, 1.186) | 0.210 |
3 | 0.577 (0.368, 0.904) | 0.016 | N | 0.879 |
> 3 | 1.528 (0.631, 3.702) | 0.348 | N | N |
Radiotherapy | ||||
Yes | Reference | Reference | ||
No | 1.550 (1.281, 1.876) | < 0.001 | 1.524 (1.230, 1.888) | < 0.001 |
Chemotherapy | ||||
Yes | Reference | Reference | ||
No | 1.664 (1.485, 1.865) | < 0.001 | 1.772 (1.559, 2.015) | < 0.001 |
Surgery | ||||
Yes | Reference | Reference | ||
No | 2.118 (1.756, 2.555) | < 0.001 | 2.115 (1.789, 2.501) | < 0.001 |