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Fig. 3 | World Journal of Surgical Oncology

Fig. 3

From: Inhibition of HIF1A-AS1 promoted starvation-induced hepatocellular carcinoma cell apoptosis by reducing HIF-1α/mTOR-mediated autophagy

Fig. 3

Inhibition of HIF1A-AS1 promoted starvation-induced HCC cell apoptosis. a, b The inhibition efficiency of siRNA targeting HIF1A-AS1 in 7721 and Huh7 HCC cell lines. qRT-PCR assay confirmed that the expression of HIF1A-AS1 was significantly decreased in 7721 and Huh7 HCC cell lines transfecting si-HIF1A-AS1. **P < 0.01 vs. si-NC group. c The role of HIF1A-AS1 on HCC cell growth viability under nutrient-deficient condition. CCK-8 assay confirmed that inhibition of HIF1A-AS1 depressed HCC cell growth. **P < 0.01 vs. si-NC group. d The role of HIF1A-AS1 on starvation-induced HCC cell apoptosis. Flow cytometry assay confirmed that inhibition of HIF1A-AS1 could enhance HCC cell apoptosis

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