Table 4 Univariate and multivariate analysis of factors associated with overall and GISTs-specific survival using Cox proportional hazards regression modeling

 No (GISTs-1)

Reference

Reference

Reference

Reference

 Yes (AM-GISTs)

1.37 (1.22–1.53)

< 0.001

1.11 (0.99–1.25)

0.085

0.76 (0.64–0.90)

0.002

0.71 (0.59–0.84)

 18–35

Reference

Reference

Reference

Reference

 36–50

1.26 (0.97–1.65)

0.084

1.26 (0.96–1.64)

0.091

1.20 (0.91–1.59)

0.192

1.21 (0.92–1.60)

 51–65

1.70 (1.32–2.19)

< 0.001

1.88 (1.46–2.43)

< 0.001

1.43 (1.10–1.87)

0.008

1.66 (1.27–2.17)

 66–80

2.94 (2.29–3.78)

< 0.001

3.28 (2.54–4.24)

< 0.001

1.90 (1.46–2.48)

< 0.001

2.29 (1.75–3.01)

 ≥ 80

6.47 (5.01–8.35)

< 0.001

6.71 (5.16–8.72)

< 0.001

3.68 (2.80–4.85)

< 0.001

4.19 (3.15–5.57)

 Male

Reference

Reference

Reference

Reference

 Female

0.78 (0.73–0.84)

< 0.001

0.71 (0.66–0.77)

< 0.001

0.77 (0.70–0.84)

< 0.001

0.76 (0.69–0.83)

 White

Reference

Reference

Reference

Reference

 Black

1.14 (1.05–1.25)

0.003

1.08 (0.98–1.19)

0.108

1.14 (1.02–1.27)

0.018

1.03 (0.92–1.16)

 Other

0.83 (0.74–0.92)

0.001

0.91 (0.81–1.02)

0.110

0.85 (0.75–0.97)

0.018

0.91 (0.79–1.04)

 Single

Reference

Reference

Reference

Reference

 Married/domestic partner

0.84 (0.76–0.93)

0.001

0.74 (0.67–0.82)

< 0.001

0.79 (0.70–0.88)

< 0.001

0.76 (0.67–0.85)

 Widowed/separated/divorced

1.44 (1.29–1.61)

< 0.001

0.99 (0.89–1.12)

0.956

1.20 (1.06–1.37)

0.006

0.97 (0.84–1.11)

 Unknown

0.84 (0.69–1.02)

0.075

0.71 (0.58–0.86)

0.001

0.71 (0.56–0.90)

0.005

0.66 (0.52–0.85)

 Stomach

Reference

Reference

Reference

Reference

 Small intestine

1.02 (0.94–1.11)

0.698

1.12 (1.02–1.22)

0.015

1.12 (1.01–1.24)

0.031

1.13 (1.01–1.25)

 Other

1.70 (1.55–1.87)

< 0.001

1.07 (0.97–1.18)

0.170

2.06 (1.85–2.30)

< 0.001

1.11 (0.99–1.25)

 No

Reference

Reference

Reference

Reference

 Yes

1.56 (1.26–1.94)

< 0.001

0.97 (0.77–1.21)

0.771

1.69 (1.32–2.17)

< 0.001

0.93 (0.72–1.20)

 Unknown

1.26 (1.15–1.37)

< 0.001

0.94 (0.85–1.03)

0.169

1.18 (1.06–1.31)

0.002

0.82 (0.74–0.92)

 0–2

Reference

Reference

Reference

Reference

 > 2 to ≤ 5

0.83 (0.69–1.01)

0.059

0.69 (0.57–0.84)

< 0.001

1.05 (0.78–1.42)

0.737

0.84 (0.62–1.14)

 > 5 to ≤ 10

1.32 (1.10–1.57)

0.003

1.04 (0.87–1.25)

0.648

2.28 (1.72–3.01)

< 0.001

1.59 (1.20–2.10)

 > 10

2.01 (1.68–2.40)

< 0.001

1.30 (1.08–1.57)

0.005

4.03 (3.06–5.31)

< 0.001

2.10 (1.58–2.78)

 Unknown

2.92 (2.44–3.50)

< 0.001

1.40 (1.16–1.70)

0.001

5.95 (4.50–7.87)

< 0.001

2.22 (1.66–2.96)

 Well differentiated

Reference

Reference

Reference

Reference

 Moderately differentiated

1.52 (1.23–1.88)

< 0.001

1.27 (1.03–1.58)

0.027

2.12 (1.58–2.86)

< 0.001

1.64 (1.21–2.21)

 Poorly differentiated

3.31 (2.64–4.15)

< 0.001

2.18 (1.73–2.74)

< 0.001

5.90 (4.38–7.97)

< 0.001

3.24 (2.40–4.39)

 Undifferentiated

3.99 (3.26–4.90)

< 0.001

2.48 (2.02–3.05)

< 0.001

7.05 (5.33–9.32)

< 0.001

3.56 (2.68–4.72)

 Unknown

2.35 (1.98–2.79)

< 0.001

1.48 (1.24–1.76)

< 0.001

3.60 (2.79–4.63)

< 0.001

1.94 (1.50–2.51)

 Localized

Reference

Reference

Reference

Reference

 Regional

1.87 (1.68–2.08)

< 0.001

1.58 (1.41–1.77)

< 0.001

2.58 (2.26–2.94)

< 0.001

1.84 (1.59–2.12)

 Distant

3.72 (3.43–4.04)

< 0.001

2.41 (2.18–2.66)

< 0.001

5.97 (5.38–6.61)

< 0.001

3.23 (2.85–3.65)

 Unstaged/unknown

2.05 (1.81–2.33)

< 0.001

1.30 (1.13–1.49)

< 0.001

2.64 (2.26–3.09)

< 0.001

1.54 (1.30–1.84)