Table 1 Patient and tumor characteristics at time of gastrointestinal stromal tumors diagnosis among 8511 patients: a SEER population-based study in US, 1988–2016
Covariates | All patients (n = 8511, %) | AM-GISTs (n = 851, %) | GISTs-1 (n = 7660, %) | p* |
|---|---|---|---|---|
Age at diagnosis, years | < 0.001 | |||
18–35 | 322 (3.8) | 7 (0.8) | 315 (4.1) | |
36–50 | 1401 (16.5) | 44 (5.2) | 1357 (17.7) | |
51–65 | 3049 (35.8) | 246 (28.9) | 2803 (36.6) | |
66–80 | 2694 (31.7) | 383 (45.0) | 2311 (30.2) | |
≥ 80 | 1045 (12.3) | 171 (20.1) | 874 (11.4) | |
Sex | 0.006 | |||
Male | 4434 (52.1) | 481 (56.5) | 3953 (51.6) | |
Female | 4077 (47.9) | 370 (43.5) | 3707 (48.4) | |
Race/ethnicity | 0.005 | |||
White | 5755 (67.6) | 606 (71.2) | 5149 (67.2) | |
Black | 1561 (18.3) | 156 (18.3) | 1405 (18.3) | |
Other† | 1195 (14.0) | 89 (10.5) | 1106 (14.4) | |
Marital status | 0.001 | |||
Single | 1386 (16.3) | 100 (11.8) | 1286 (16.8) | |
Married/domestic partner | 4909 (57.7) | 504 (59.2) | 4405 (57.5) | |
Widowed/separated/divorced | 1799 (21.1) | 207 (24.3) | 1592 (20.8) | |
Unknown | 417 (4.9) | 40 (4.7) | 377 (4.9) | |
%< High school education, tertile | 0.038 | |||
First tertile | 2812 (33.0) | 307 (36.1) | 2505 (32.7) | |
Second tertile | 3004 (35.3) | 305 (35.8) | 2699 (35.2) | |
Third tertile | 2695 (31.7) | 239 (28.1) | 2456 (32.1) | |
Median household income, tertile | 0.478 | |||
First tertile | 2811 (33.0) | 278 (32.7) | 2533 (33.1) | |
Second tertile | 2830 (33.3) | 271 (31.8) | 2559 (33.4) | |
Third tertile | 2870 (33.7) | 302 (35.5) | 2568 (33.5) | |
Year of diagnosis | < 0.001 | |||
1988–2002 | 1139 (13.4) | 81 (9.5) | 1058 (13.8) | |
2003–2016 | 7372 (86.6) | 770 (90.5) | 6602 (86.2) | |
Primary site | 0.309 | |||
Stomach | 4960 (58.3) | 515 (60.5) | 4445 (58.0) | |
Small intestine | 2329 (27.4) | 215 (25.3) | 2114 (27.6) | |
Other | 1222 (14.4) | 121 (14.2) | 1101 (14.4) | |
Chemotherapy | < 0.001 | |||
Yes | 3440 (40.4) | 282 (33.1) | 3158 (41.2) | |
No/unknown | 5071 (59.6) | 569 (66.9) | 4502 (58.8) | |
Surgery of primary | 0.386 | |||
Yes | 6566 (77.1) | 641 (75.3) | 5925 (77.3) | |
No | 1766 (20.7) | 192 (22.6) | 1574 (20.5) | |
Unknown | 179 (2.1) | 18 (2.1) | 161 (2.1) | |
Lymph node metastasis | 0.024 | |||
Yes | 200 (2.3) | 14 (1.6) | 186 (2.4) | |
No | 1966 (23.1) | 171 (20.1) | 1795 (23.4) | |
Unknown | 6345 (74.6) | 666 (78.3) | 5679 (74.1) | |
Tumor size, cm | < 0.001 | |||
0–2 | 602 (7.1) | 106 (12.5) | 496 (6.5) | |
> 2 to ≤ 5 | 1908 (22.4) | 208 (24.4) | 1700 (22.2) | |
> 5 to ≤ 10 | 2311 (27.2) | 199 (23.4) | 2112 (27.6) | |
> 10 | 1933 (22.7) | 159 (18.7) | 1774 (23.2) | |
Unknown | 1757 (20.6) | 179 (21.0) | 1578 (20.6) | |
Grade | 0.184 | |||
Well differentiated | 1077 (12.7) | 121 (14.2) | 956 (12.5) | |
Moderately differentiated | 900 (10.6) | 104 (12.2) | 796 (10.4) | |
Poorly differentiated | 361 (4.2) | 30 (3.5) | 331 (4.3) | |
Undifferentiated | 544 (6.4) | 52 (6.1) | 492 (6.4) | |
Unknown | 5629 (66.1) | 544 (63.9) | 5085 (66.4) | |
SEER stages | < 0.001 | |||
Localized | 4483 (52.7) | 493 (57.9) | 3990 (52.1) | |
Regional | 1033 (12.1) | 74 (8.7) | 959 (12.5) | |
Distant | 1739 (20.4) | 135 (15.9) | 1604 (20.9) | |
Unstaged/unknown | 1256 (14.8) | 149 (17.5) | 1107 (14.5) | |
Latency‡ | NA | |||
≥ 2 months to 5 years | NA | 496 (58.3) | NA | |
> 5–10 years | NA | 281 (20.9) | NA | |
> 10–15 years | NA | 103 (12.1) | NA | |
> 15–20 years | NA | 42 (4.9) | NA | |
> 20 years | NA | 32 (3.8) | NA |