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Table 2 Multivariate Cox proportional hazard model for overall survival and disease-free survival of advanced HPSCC patients

From: Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma

VariableOSDFS
HR (95% CI)p valueHR (95% CI)p value
Sex
 FemaleReference Reference 
 Male1.74 (0.82–3.68)0.1501.39 (0.72–2.70)0.332
Age (years)
 < 65Reference Reference 
 ≥ 651.01 (0.76–1.36)0.9290.97 (0.73–1.28)0.965
Overall stages
 IIIReference Reference 
 IVA1.67 (1.18–2.35)0.0041.64 (1.19–2.26)0.057
 IVB2 98 (2.05–4.33)< 0.0013.01 (2.12–4.27)< 0.001
Histology grade
 WD/MDReference Reference 
 PD/UD0.99 (0.73–1.34)0.9440.97 (0.72–1.30)0.826
 Unclassified1.06 (0.83–1.35)0.6321.10 (0.87–1.38)0.440
Treatment
 CCRTReference Reference 
 Surgery0.73 (0.57–0.94)0.0140.83 (0.66–1.04)0.105
  1. OS overall survival, DFS disease-free survival, WD well differentiated, MD moderately differentiated, PD poorly differentiated, UD undifferentiated, CCRT concurrent chemoradiotherapy