Table 3 Univariate and maltivariate analysis of the association between preoperative clinicopathological factors and overall survival in patients with distal bile duct cancer who underwent pancreaticoduodenectomy

Age (years)

≥ 65

31 (82%)

0.508

0.2046–1.245

0.138

< 65

9 (22%)

(Referent)

Gender

Male

0.945

0.352–3.282

0.920

Female

(Referent)

Differentiation

Well differentiated

8 (20%)

1.243

0.416–3.716

0.697

Others

32 (80%)

(Referent)

T classification

T1/2

10 (25%)

(Referent)

0.6476–5.816

0.236

T3/4

30 (75%)

1.941

N classification

N (−)

21 (53%)

(Referent)

1.078–5.772

0.033

N (+)

19 (48%)

2.495

Resection margin

R0

29 (73%)

(Referent)

0.9687–5.581

0.059

R1 or R2

11 (27%)

2.325

Albumin (g/dL)

≥ 3.5

24 (60%)

(Referent)

1.521–8.495

0.004

1.484

0.537–4.107

0.447

< 3.5

16 (40%)

3.595

CRP (mg/dL)

≥ 0.5

16 (40%)

1.220

0.5223–2.85

0.646

< 0.5

24 (60%)

(Referent)

CEA (ng/mL)

≥ 2.5

21 (53%)

1.665

0.7226–3.838

0.231

< 2.5

19 (48%)

(Referent)

CA19-9 (U/mL)

≥ 60.2

19 (48%)

3.165

1.345–7.449

0.008

2.614

0.978–6.993

0.056

< 60.2

21 (53%)

(Referent)

NLR

≥ 3.14

8 (20%)

11.810

3.296–42.32

< 0.001

6.133

1.453–25.900

0.014

< 3.14

32 (80%)

(Referent)

LMR

≥ 4.55

18 (45%)

(Referent)

1.826–12.81

0.002

3.16

1.024–9.751

0.045

< 4.55

22 (55%)

4.837