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Table 3 Univariate and maltivariate analysis of the association between preoperative clinicopathological factors and overall survival in patients with distal bile duct cancer who underwent pancreaticoduodenectomy

From: The prognostic impact of neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) in patients with distal bile duct cancer

Factors No. (%) Univariate analysis Multivariate analysis
Hazard ratio 95% CI P value Hazard ratio 95% CI P value
Age (years) ≥ 65 31 (82%) 0.508 0.2046–1.245 0.138    
< 65 9 (22%) (Referent)
Gender Male 33 (87%) 0.945 0.352–3.282 0.920    
Female 7 (13%) (Referent)
Differentiation Well differentiated 8 (20%) 1.243 0.416–3.716 0.697    
Others 32 (80%) (Referent)
T classification T1/2 10 (25%) (Referent) 0.6476–5.816 0.236    
T3/4 30 (75%) 1.941
N classification N (−) 21 (53%) (Referent) 1.078–5.772 0.033    
N (+) 19 (48%) 2.495
Resection margin R0 29 (73%) (Referent) 0.9687–5.581 0.059    
R1 or R2 11 (27%) 2.325
Albumin (g/dL) ≥ 3.5 24 (60%) (Referent) 1.521–8.495 0.004 1.484 0.537–4.107 0.447
< 3.5 16 (40%) 3.595
CRP (mg/dL) ≥ 0.5 16 (40%) 1.220 0.5223–2.85 0.646    
< 0.5 24 (60%) (Referent)
CEA (ng/mL) ≥ 2.5 21 (53%) 1.665 0.7226–3.838 0.231    
< 2.5 19 (48%) (Referent)
CA19-9 (U/mL) ≥ 60.2 19 (48%) 3.165 1.345–7.449 0.008 2.614 0.978–6.993 0.056
< 60.2 21 (53%) (Referent)
NLR ≥ 3.14 8 (20%) 11.810 3.296–42.32 < 0.001 6.133 1.453–25.900 0.014
< 3.14 32 (80%) (Referent)
LMR ≥ 4.55 18 (45%) (Referent) 1.826–12.81 0.002 3.16 1.024–9.751 0.045
< 4.55 22 (55%) 4.837