Metastatic colorectal cancer prior to expanded RAS assessment: evidence from long-term outcome analysis of a real-life cohort within a dedicated colorectal cancer unit

Table 4 PFS and OS multivariate Cox regression analyses of the whole series

	First line PFS			OS
Variable	HR	95% CI	3.3. p	HR	95% CI	p
Gender	0.86	0.69–1.08	0.199	1.21	0.96–1.54	0.109
Age at metastasis	1.01	0.99–1.02	0.180	1.02	1.00–1.04	0.009
Chemotherapy plus bevacizumab versus other	0.70	0.66–0.74	< 0.001	–	–	–
Surgical resection of metastasis (Yes versus No)	0.57	0.44–0.71	< 0.001	0.49	0.39–0.61	< 0.001
Right-sided tumor versus other (left-sided and rectum)	–	–	–	1.18	1.00–1.40	0.048
**KRASmutant (exon 2) versus wild-type**	–	–	–	1.28	0.75–2.18	0.365

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