Table 1 Clinico-pathological characteristics according to long-term survival status

Gender

Female

102

79

23

0.613

Male

146

109

37

Age at diagnosis

Median (range) (years)

65 (32–82)

66 (37–82)

60 (32-82)

0.012

Age at metastasis

Median (range) (years)

65 (35–83)

66 (37–83)

62 (35–83)

0.026

Mutational statusKRAS(exon 2)

WT

136

100

36

0.651

Codon 12 mutation

88

69

19

Codon 13 mutation

24

19

5

Grading (not available 5; surgical resection of primary tumor not performed 30)

1

7

5

2

0.646

2

140

102

38

3

66

52

14

pT

(not available 1; surgical resection of primary tumor not performed 30)

1

3

1

2

0.052

2

11

7

4

3

136

97

39

4

72

55

12

Primary site

Right side

83

69

14

0.150

Left side

97

71

26

Rectum

68

48

20

Primary site

Right side

83

69

14

0.056

Left side + Rectum

165

119

46

Metastasis at diagnosis

No

89

63

26

0.167

Yes

159

125

34

Metastatic site

Liver

98

70

28

0.301

Lung

18

12

6

Peritoneum

15

11

4

Lymph nodes

5

3

2

Multiple sites

111

91

20

Number of metastatic sites

Single site

136

96

40

0.038

Multiple sites

111

91

20

Surgical resection of primary tumor

No

30

27

3

0.053

Yes

218

161

57

Adjuvant treatment

No

169

132

37

0.216

Yes

79

56

23

Metastasis surgical resection

No

159

140

22

<0.001

Yes

89

48

38

Local non-surgical treatment of metastasis

No

174

148

26

<0.001

Yes

74

40

34