From: Postoperative pain pathophysiology and treatment strategies after CRS + HIPEC for peritoneal cancer
Analgesic | |
 Acetaminophen, NSAIDs, COX-2 inhibitor [59], gabapentin [60] | There was no alleviation of perioperative inflammation with the preoperative administration of celecoxib, tramadol and pregabalin, and intraoperative TIVA combined with propofol, dexmedetomidine, ketamine, and lidocaine [61]. |
 Propofol [62], dexmedetomidine [63], ketamine [64, 65], and lidocaine [66] have independent anti-inflammatory properties. | |
 Calcium channel α-2-δ ligand anticonvulsant drugs, tricyclic antidepressants, selective 5-HT, and norepinephrine reuptake inhibitors | They provide symptomatic reliefs and the effects are often limited. |
Regional nerve block | Â |
 TEA combined with opioids has the advantages of analgesia, early extubation after surgery, lower postoperative pulmonary complications, and reduced incidence of postoperative complications [67,68,69,70] | TEA is a safe option for CRS + HIPEC treatment, regardless of some fluctuations in intraoperative coagulation measurements [71, 72]. |