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Table 4 Risk factors for lymph node metastasis in mucosal and submucosal gastric cancer

From: Analysis of lymph node metastasis in early gastric cancer: a single institutional experience from China

VariablesMucosal gastric cancerSubmucosal gastric cancer
 LN (−) (N = 464)LN (+) (N = 44)PLN (−) (N = 396)LN (+) (N = 129)P
Age, years56.4 ± 11.249.8 ± 11.6< 0.00158.7 ± 10.255.7 ± 10.80.005
Sex, n (%)  < 0.001  0.001
 Male301 (95.9)13 (4.1) 282 (79.7)72 (20.3) 
 Female163 (84.0)31 (16.0) 114 (66.7)57 (33.3) 
Location, n (%)  0.25  0.226
 Upper36 (97.3)1 (2.7) 57 (83.8)11 (16.2) 
 Middle92 (88.5)12 (11.5) 74 (84.0)26 (26.0) 
 Lower336 (91.6)31 (8.4) 265 (74.2)92 (25.8) 
Tumor size, cm1.9 ± 1.12.6 ± 1.4< 0.0012.2 ± 1.12.5 ± 1.20.007
Retrieved LN24.3 ± 8.126.3 ± 9.00.12623.3 ± 7.624.7 ± 9.50.085
Lymphovascular invasion, n (%)  < 0.001  < 0.001
 Negative456 (92.5)37 (7.5) 359 (81.8)80 (18.2) 
 Positive8 (53.3)7 (46.7) 37 (43.0)49 (57.0) 
Perineural invasion, n (%)  NA  < 0.001
 Negative464 (91.3)44 (8.7) 382 (77.5)111 (22.5) 
 Positive0 (0.0)0 (0.0) 14 (43.8)18 (56.2) 
Differentiation, n (%)     < 0.001
 D-type214 (98.6)3 (1.4)< 0.001183 (84.3)34 (15.7) 
 UD-type250 (85.9)41 (14.1) 213 (69.2)95 (30.8) 
Lauren classificationa, n (%)  < 0.001  < 0.001
 Intestinal207 (97.1)6 (2.9) 220 (84.0)42 (16.0) 
 Diffuse139 (85.7)23 (14.3) 79 (64.8)43 (35.2) 
 Mixed68 (88.3)9 (11.7) 59 (63.4)34 (36.6) 
  1. D-type differentiated-type, LN lymph node, NA not available, UD-type undifferentiated-type
  2. aThere are some patients with unknown information about the Lauren classification