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Table 1 Clinicopathologic characteristics and outcomes stratified by neoadjuvant treatment (values in either median ± SD or no. (%) unless otherwise stated)

From: A lower cut-off for lymph node harvest predicts for poorer overall survival after rectal surgery post neoadjuvant chemoradiotherapy

VariableCategoryTotal (N = 257)Upfront surgery (N = 163)NACRT group (N = 94)P value
Age at diagnosis (years)66 ± 1167 ± 1164 ± 100.132
GenderMale174 (68)106 (65)68 (72)0.227
Female83 (32)57 (35)26 (28)
Distance from anal verge (centimetres)6 ± 37.0 ± 3.45.5 ± 2.4< 0.001
Type of operationUltra-low anterior resection32 (12)16 (10)16 (13)0.001
Low anterior resection168 (65)117 (72)51 (65)
Hartmann’s procedure19 (8)15 (9)4 (7)
Abdominoperineal resection38 (15)15 (9)23 (15)
Lymph node harvest17 ± 1123 ± 1314 ± 6.7< 0.001
Lymph node harvest< 1253 (21)17 (10)36 (38)0.002
≥ 12204 (79)146 (90)58 (62)
Post-operative complicationsNone225 (88)140 (86)85 (88)0.729
Clavien-Dindo 1 and 227 (11)19 (11)8 (10)
Clavien-Dindo 3 and above5 (1)4 (3)1 (2)
Length of stay (days)9 ± 810 ± 88 ± 80.190
30-day mortalityYes255 (99)2 (1)0 (0)0.281
No2 (1)161 (99)94 (100)
RecurrenceYes60 (23)40 (25)20 (21)0.551
No197 (77)123 (75)74 (79)
Disease-free survival (months)66 ± 4162 ± 4073 ± 420.067
MortalityYes90 (35)60 (37)30 (32)0.428
No167 (65)103 (63)64 (68)
Overall survival (months)71 ± 3868 ± 3877 ± 390.059
  1. NACRT neoadjuvant chemoradiotherapy