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Table 1 The quality of each study evaluated using Jadad’s score

From: Neoadjuvant strategies in resectable carcinoma esophagus: a meta-analysis of randomized trials

 Study and reference no.ArmsSample sizeTreatment scheduleNo. of cyclesJadad’s score
RBDTotal
1.Ancona et al. (2001) [3]NACT vs Sx96Cisplatin 100 mg/m2on day 1
5-Fluorouracil 1000 mg/m2 days 1 to 5
02 (21-day cycle)1 + 1013
2.Kelson et al. (1998) [4]NACT vs Sx440Cisplatin 100 mg/m2 on day 1
5-Fluorouracil 1000 mg/m2 days 1 to 5
03 (29-day cycle)1 + 1013
3.Law et al. (1997) [5]NACT vs Sx147Cisplatin 100 mg/m2 on day 1
5-Fluorouracil 1000 mg/m2 days 1 to 5
02 (22–26-day cycle)1012
4.MRC (2002) [9]NACT vs Sx802Cisplatin 100 mg/m2 on day 1
5-Fluorouracil 1000 mg/m2 days 1 to 4
02 (21-day cycle)1 + 1013
5.Maipang et al. (1994) [7]NACT vs Sx46Cisplatin 100 mg/m2 on day 1
Vinblastine, 3 mg/m2 on days 1, 8, 15, and 22
Bleomycin 10 mg/m2, on day 3 followed by a 4-day infusion of 10 mg/m2/day
02 (29-day cycle)1012
6.Boonstra et al. (2011) [23]NACT vs Sx169Cisplatin 100 mg/m2 on day 1, Etoposide 100 mg/m2 intravenously on days 1 and 2, followed by Etoposide 200 mg/m2 orally on days 3–5.03 (28-day cycle)1012
7.Baba et al. (2000) [22]NACT vs Sx21Cisplatin 70 mg/m2on day 1
5-Fluorouracil 700 mg/m2 days 1 to 5
Leucovorin 20 mg/m2days 1 to 5
02 (28-32 day cycle)1 + 1013
8.Bosset et al. (1997) [24]NACRT vs Sx282Cisplatin 80 mg/m2on days 0–2
Total radiation dose: 37.5 Gy
021012
9.Urba et al. (2001) [18]NACRT vs Sx100Cisplatin 20 mg/m2 days 1–5
5-Fluorouracil 300 mg/m2 days 1–21
Vinblastine 1 mg/m2 days 1–4
Total radiation dose: 45 Gy
021012
10.NEOCTREC (2018) [11]NACRT vs Sx451Cisplatin 75 mg/m2 day 1 or Cisplatin 25 mg/m2 days 1 to 4
Vinorelbine 25 mg/m2days 1 and 8
Total radiation dose: 40 Gy
021 + 101 
11.Lee et al. (2004) [6]NACRT vs Sx101Cisplatin 60 mg/m2day 1
5-Fluorouracil 1000 mg/m2 days 2 to 5
Total radiation dose: 45.6 Gy
021 + 1013
12.Shapiro et al. (2015) [16]NACRT vs Sx366Carboplatin AUC 2 mg/ml/min day 1
Paclitaxel 50 mg/m2 day 1
Total radiation dose: 41.4 Gy
051 + 1013
13.Natsugoe et al. (2006) [10]NACRT vs Sx45Cisplatin 7 mg
5-Fluorouracil 350 mg
Total radiation dose: 40 Gy
201 + 1013
14.Tepper et al. (2008) [17]NACRT vs Sx56Cisplatin 100 mg/m2 day 1
5-Fluorouracil 1000 mg/m2 days 1–4
Total radiation dose: 50.4 Gy
021012
15.Mariette et al. (2014) [8]NACRT vs Sx195Cisplatin 75 mg/m2 day 1
5-Fluorouracil 800 mg/m2 days 1–4
Total radiation dose: 45 Gy
021 + 1013
16.Lv et al. (2010) [34]NACRT vs Sx238Cisplatin20 mg/m2days 1–3
Paclitaxel 135 mg/m2 day 1
Total radiation dose: 40 Gy
021 + 1002
17.Walsh et al. (1996) [19]NACRT vs Sx113Cisplatin75 mg/m2 day 7
5-Fluorouracil 15 mg/kg/day days 1–5
Total radiation dose: 40 Gy
021012
18.Burmeister et al. (2005) [25]NACRT vs Sx256Cisplatin 80 mg/m2
5-Fluorouracil 800 mg/m2 days 1–4
Total radiation dose: 35 Gy
011 + 1013
19.Le Prise et al. (1994) [13]SCRT vs Sx104Cisplatin 100 mg/m2 day 1
5-Fluorouracil 600 mg/m2 days 2–5
Total radiation dose: 20 Gy
020011
20.Wang et al. (1998) [20]NART vs Sx206Total radiation dose: 40 Gy 1001
21.Lanouis et al. (1981) [35]NART
vs Sx
124Total radiation dose: 40 Gy 1012
22.Gignoux et al. (1987) [27]NART
vs Sx
126Total radiation dose: 33 Gy 1001
23.Arnott et al. (1992) [21]NART
vs Sx
129Total radiation dose: 20 Gy 1 + 1013
24.Nygaard et al. (1992) [12]NACT
vs SCRT vs NART vs Sx
186Cisplatin 20 mg/m2days 1 to 5
Bleomycin 50 mg/m2 days 1–5
Total radiation dose: 35
02 (15–23-day cycle)1012
25.Cao et al. (2009) [26]NACT
vs NACRT vs NART vs Sx
473Cisplatin 20 mg/m2 days 1–5
5-Fluorouracil 500 mg/m2 days 1–5
Mitomycin 10 mg/m [2]/day, day 1
Total radiation dose: 40 Gy
NA1001
  1. NACT neoadjuvant chemotherapy, NACRT neoadjuvant concurrent chemoradiation, NART neoadjuvant chemoradiation, SCRT neoadjuvant sequential chemoradiation, Sx surgery, R randomization, B blinding, D description