Table 1 The quality of each study evaluated using Jadad’s score
From: Neoadjuvant strategies in resectable carcinoma esophagus: a meta-analysis of randomized trials
Study and reference no. | Arms | Sample size | Treatment schedule | No. of cycles | Jadad’s score | ||||
|---|---|---|---|---|---|---|---|---|---|
R | B | D | Total | ||||||
1. | Ancona et al. (2001) [3] | NACT vs Sx | 96 | Cisplatin 100 mg/m2on day 1 5-Fluorouracil 1000 mg/m2 days 1 to 5 | 02 (21-day cycle) | 1 + 1 | 0 | 1 | 3 |
2. | Kelson et al. (1998) [4] | NACT vs Sx | 440 | Cisplatin 100 mg/m2 on day 1 5-Fluorouracil 1000 mg/m2 days 1 to 5 | 03 (29-day cycle) | 1 + 1 | 0 | 1 | 3 |
3. | Law et al. (1997) [5] | NACT vs Sx | 147 | Cisplatin 100 mg/m2 on day 1 5-Fluorouracil 1000 mg/m2 days 1 to 5 | 02 (22–26-day cycle) | 1 | 0 | 1 | 2 |
4. | MRC (2002) [9] | NACT vs Sx | 802 | Cisplatin 100 mg/m2 on day 1 5-Fluorouracil 1000 mg/m2 days 1 to 4 | 02 (21-day cycle) | 1 + 1 | 0 | 1 | 3 |
5. | Maipang et al. (1994) [7] | NACT vs Sx | 46 | Cisplatin 100 mg/m2 on day 1 Vinblastine, 3 mg/m2 on days 1, 8, 15, and 22 Bleomycin 10 mg/m2, on day 3 followed by a 4-day infusion of 10 mg/m2/day | 02 (29-day cycle) | 1 | 0 | 1 | 2 |
6. | Boonstra et al. (2011) [23] | NACT vs Sx | 169 | Cisplatin 100 mg/m2 on day 1, Etoposide 100 mg/m2 intravenously on days 1 and 2, followed by Etoposide 200 mg/m2 orally on days 3–5. | 03 (28-day cycle) | 1 | 0 | 1 | 2 |
7. | Baba et al. (2000) [22] | NACT vs Sx | 21 | Cisplatin 70 mg/m2on day 1 5-Fluorouracil 700 mg/m2 days 1 to 5 Leucovorin 20 mg/m2days 1 to 5 | 02 (28-32 day cycle) | 1 + 1 | 0 | 1 | 3 |
8. | Bosset et al. (1997) [24] | NACRT vs Sx | 282 | Cisplatin 80 mg/m2on days 0–2 Total radiation dose: 37.5 Gy | 02 | 1 | 0 | 1 | 2 |
9. | Urba et al. (2001) [18] | NACRT vs Sx | 100 | Cisplatin 20 mg/m2 days 1–5 5-Fluorouracil 300 mg/m2 days 1–21 Vinblastine 1 mg/m2 days 1–4 Total radiation dose: 45 Gy | 02 | 1 | 0 | 1 | 2 |
10. | NEOCTREC (2018) [11] | NACRT vs Sx | 451 | Cisplatin 75 mg/m2 day 1 or Cisplatin 25 mg/m2 days 1 to 4 Vinorelbine 25 mg/m2days 1 and 8 Total radiation dose: 40 Gy | 02 | 1 + 1 | 0 | 1 | |
11. | Lee et al. (2004) [6] | NACRT vs Sx | 101 | Cisplatin 60 mg/m2day 1 5-Fluorouracil 1000 mg/m2 days 2 to 5 Total radiation dose: 45.6 Gy | 02 | 1 + 1 | 0 | 1 | 3 |
12. | Shapiro et al. (2015) [16] | NACRT vs Sx | 366 | Carboplatin AUC 2 mg/ml/min day 1 Paclitaxel 50 mg/m2 day 1 Total radiation dose: 41.4 Gy | 05 | 1 + 1 | 0 | 1 | 3 |
13. | Natsugoe et al. (2006) [10] | NACRT vs Sx | 45 | Cisplatin 7 mg 5-Fluorouracil 350 mg Total radiation dose: 40 Gy | 20 | 1 + 1 | 0 | 1 | 3 |
14. | Tepper et al. (2008) [17] | NACRT vs Sx | 56 | Cisplatin 100 mg/m2 day 1 5-Fluorouracil 1000 mg/m2 days 1–4 Total radiation dose: 50.4 Gy | 02 | 1 | 0 | 1 | 2 |
15. | Mariette et al. (2014) [8] | NACRT vs Sx | 195 | Cisplatin 75 mg/m2 day 1 5-Fluorouracil 800 mg/m2 days 1–4 Total radiation dose: 45 Gy | 02 | 1 + 1 | 0 | 1 | 3 |
16. | Lv et al. (2010) [34] | NACRT vs Sx | 238 | Cisplatin20 mg/m2days 1–3 Paclitaxel 135 mg/m2 day 1 Total radiation dose: 40 Gy | 02 | 1 + 1 | 0 | 0 | 2 |
17. | Walsh et al. (1996) [19] | NACRT vs Sx | 113 | Cisplatin75 mg/m2 day 7 5-Fluorouracil 15 mg/kg/day days 1–5 Total radiation dose: 40 Gy | 02 | 1 | 0 | 1 | 2 |
18. | Burmeister et al. (2005) [25] | NACRT vs Sx | 256 | Cisplatin 80 mg/m2 5-Fluorouracil 800 mg/m2 days 1–4 Total radiation dose: 35 Gy | 01 | 1 + 1 | 0 | 1 | 3 |
19. | Le Prise et al. (1994) [13] | SCRT vs Sx | 104 | Cisplatin 100 mg/m2 day 1 5-Fluorouracil 600 mg/m2 days 2–5 Total radiation dose: 20 Gy | 02 | 0 | 0 | 1 | 1 |
20. | Wang et al. (1998) [20] | NART vs Sx | 206 | Total radiation dose: 40 Gy | 1 | 0 | 0 | 1 | |
21. | Lanouis et al. (1981) [35] | NART vs Sx | 124 | Total radiation dose: 40 Gy | 1 | 0 | 1 | 2 | |
22. | Gignoux et al. (1987) [27] | NART vs Sx | 126 | Total radiation dose: 33 Gy | 1 | 0 | 0 | 1 | |
23. | Arnott et al. (1992) [21] | NART vs Sx | 129 | Total radiation dose: 20 Gy | 1 + 1 | 0 | 1 | 3 | |
24. | Nygaard et al. (1992) [12] | NACT vs SCRT vs NART vs Sx | 186 | Cisplatin 20 mg/m2days 1 to 5 Bleomycin 50 mg/m2 days 1–5 Total radiation dose: 35 | 02 (15–23-day cycle) | 1 | 0 | 1 | 2 |
25. | Cao et al. (2009) [26] | NACT vs NACRT vs NART vs Sx | 473 | Cisplatin 20 mg/m2 days 1–5 5-Fluorouracil 500 mg/m2 days 1–5 Mitomycin 10 mg/m [2]/day, day 1 Total radiation dose: 40 Gy | NA | 1 | 0 | 0 | 1 |