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Table 2 Functional enrichment analysis of the overlapping DEGs

From: Identification of key differentially expressed genes and gene mutations in breast ductal carcinoma in situ using RNA-seq analysis

GO Term

Gene Counts

TF Genes

p value

Downregulated overlapping DEGs

Translation

38

 

3.88E-06

Positive regulation of programmed cell death

41

HIP1, ID3, IFI16, NR3C1, PML, RXRA, TP53BP2

1.36E-04

RNA processing

46

 

7.09E-04

Regulation of cell migration

20

 

8.03E-04

Negative regulation of cell proliferation

33

ESR2, NKX3-1, NME2, PML, RXRA

0.001239

Regulation of lipid metabolic process

15

NR3C1, NR5A1, PPARA

0.001380

Cell adhesion

52

LEF1, NME2

0.004558

JNK cascade

9

 

0.008755

Cellular protein localization

33

 

0.008962

Response to hormone stimulus

30

ESR2, PPARA, RXRA

0.010205

Upregulated overlapping DEGs

Positive regulation of tumor necrosis factor production

4

 

0.005861

Regulation of tumor necrosis factor production

5

 

0.007442

Response to lipopolysaccharide

7

NKX2-1

0.013341

Small GTPase mediated signal transduction

15

 

0.024022

Cytokine production

5

 

0.028739

Regulation of phosphate metabolic process

20

 

0.040473

Regulation of cAMP biosynthetic process

7

 

0.043362

Blood circulation

10

 

0.047845

  1. DEGs differentially expressed genes, TF transcription factor, GO gene ontology