Table 1 Gene Ontology and KEGG pathway analysis of DEGs in colorectal cancer

Upregulated

GOTERM_BP_FAT

GO:0000280~nuclear division

40

1.34E−18

GOTERM_BP_FAT

GO:0048285~organelle fission

40

1.23E−17

GOTERM_BP_FAT

GO:0051301~cell division

37

2.68E−16

GOTERM_BP_FAT

GO:0022402~cell cycle process

56

4.22E−16

GOTERM_BP_FAT

GO:0007049~cell cycle

61

3.43E−15

GOTERM_CC_FAT

GO:0005694~chromosome

41

1.95E−11

GOTERM_CC_FAT

GO:0000775~chromosome, centromeric region

18

4.41E−10

GOTERM_CC_FAT

GO:0005819~spindle

22

4.71E−10

GOTERM_CC_FAT

GO:0044427~chromosomal part

36

5.61E−10

GOTERM_CC_FAT

GO:0098687~chromosomal region

22

5.14E−09

GOTERM_MF_FAT

GO:0003777~microtubule motor activity

10

4.37E−07

GOTERM_MF_FAT

GO:0008009~chemokine activity

7

2.38E−05

GOTERM_MF_FAT

GO:0003774~motor activity

10

4.01E−05

GOTERM_MF_FAT

GO:0045236~CXCR chemokine receptor binding

5

4.08E−05

GOTERM_MF_FAT

GO:0005125~cytokine activity

12

7.12E−05

KEGG_PATHWAY

hsa04110:Cell cycle

15

9.41E−10

KEGG_PATHWAY

hsa04114:Oocyte meiosis

10

1.81E−05

KEGG_PATHWAY

hsa04914:Progesterone-mediated oocyte maturation

9

2.17E−05

KEGG_PATHWAY

hsa04060:Cytokine-cytokine receptor interaction

13

1.05E−04

KEGG_PATHWAY

hsa05322:Systemic lupus erythematosus

8

0.002278

Downregulated

GOTERM_BP_FAT

GO:0003012~muscle system process

43

1.93E−15

GOTERM_BP_FAT

GO:0044057~regulation of system process

45

1.99E−13

GOTERM_BP_FAT

GO:0006936~muscle contraction

33

3.28E−11

GOTERM_BP_FAT

GO:0003008~system process

96

1.06E−10

GOTERM_BP_FAT

GO:0007399~nervous system development

100

2.43E−10

GOTERM_CC_FAT

GO:0043005~neuron projection

60

1.19E−10

GOTERM_CC_FAT

GO:0042383~sarcolemma

19

5.73E−10

GOTERM_CC_FAT

GO:0097458~neuron part

67

4.47E−08

GOTERM_CC_FAT

GO:0044449~contractile fiber part

22

4.57E−08

GOTERM_CC_FAT

GO:0030425~dendrite

34

7.24E−08

GOTERM_MF_FAT

GO:0005216~ion channel activity

32

5.05E−08

GOTERM_MF_FAT

GO:0015267~channel activity

34

5.49E−08

GOTERM_MF_FAT

GO:0022803~passive transmembrane transporter activity

34

5.77E−08

GOTERM_MF_FAT

GO:0022838~substrate-specific channel activity

32

1.16E−07

GOTERM_MF_FAT

GO:0005539~glycosaminoglycan binding

20

6.73E−07

KEGG_PATHWAY

hsa04022:cGMP-PKG signaling pathway

13

8.87E−04

KEGG_PATHWAY

hsa05410:Hypertrophic cardiomyopathy (HCM)

9

9.58E−04

KEGG_PATHWAY

hsa05414:Dilated cardiomyopathy

9

0.001557

KEGG_PATHWAY

hsa04920:Adipocytokine signaling pathway

8

0.002302

KEGG_PATHWAY

hsa04261:Adrenergic signaling in cardiomyocytes

11

0.00334