Table 2 Predictive factors for LNM in EGC patients (596 cases)

Age, no. (%)

0.901

 < 60 years

271 (45.5)

Reference

 ≥ 60 years

325 (54.5)

1.03 (0.67–1.59)

BMI, no. (%)

0.052

 < 18.5 kg/m²

39 (6.5)

2.38 (1.08–5.22)

 ≥ 18.5 kg/m², < 25 kg/m²

373 (62.6)

0.96 (0.59–1.57)

 ≥ 25 kg/m²

184 (30.9)

Reference

Gender, no. (%)

0.891

 Female

179 (30.0)

Reference

 Male

417 (70.0)

0.97 (0.61–1.55)

Tumor size level, no. (%)

< 0.001

< 0.001

 < 2.20 cm

390 (65.4)

Reference

Reference

 ≥ 2.20 cm

206 (34.6)

3.09 (1.99–4.82)

3.18 (1.91–5.30)

Tumor location, no. (%)

0.046

 Cardia

69 (11.6)

Reference

 Corpus/fundus

121 (20.3)

4.02 (1.33–12.13)

 Antrum/angularis/pylorus

406 (68.1)

3.39 (1.19–9.60)

Macroscopic feature, no. (%)

0.005

0.027

 Flat type (IIb)

201 (33.7)

Reference

Reference

 Elevated type (I + IIa)

113 (19.0)

1.72 (0.87–3.40)

1.80 (0.85–3.80)

 Depressed type (IIc + III)

282 (47.3)

2.45 (1.42–4.21)

2.29 (1.25–4.20)

Histology grades, no. (%)

< 0.001

< 0.001

 Well

58 (9.7)

Reference

Reference

 Moderate

319 (53.5)

8.64 (1.17–64.09)

8.75 (1.11–68.78)

 Poorly

219 (36.7)

19.12 (2.59–141.32)

30.76 (3.85–245.97)

Topo II, no. (%)

0.243

 Negative

248 (41.6)

Reference

 Positive

348 (58.4)

0.77 (0.50–1.19)

P53, no. (%)

0.014

< 0.001

 Negative

353 (59.2)

Reference

Reference

 Positive

342 (40.8)

1.73 (1.12–2.67)

3.32 (1.93–5.72)

Ki67, no. (%)

0.234

 Negative

18 (3.0)

Reference

 Positive

578 (97.0)

3.43 (0.45–26.07)

CEA, no. (%)

0.058

 < 5 ng/mL

551 (92.4)

Reference

 ≥ 5 ng/mL

45 (7.6)

1.97 (0.98–3.96)

CA19-9 level, no. (%)

< 0.001

< 0.001

 < 36.78 U/mL

570 (95.6)

Reference

Reference

 ≥ 36.78 U/mL

26 (4.4)

11.40 (4.92–26.45)

9.63 (3.75–24.72)

CA72-4, no. (%)

0.640

 < 9.8 U/mL

502 (84.2)

 ≥ 9.8 U/mL

94 (15.8)

1.15 (0.65–2.04)

CT-reported LN status, no. (%)

< 0.001

< 0.001

 Negative

475 (79.7)

Reference

Reference

 Positive

121 (20.3)

3.17 (1.98–5.07)

2.91 (1.69–5.00)