Safety and efficacy of en bloc transurethral resection versus conventional transurethral resection for primary nonmuscle-invasive bladder cancer: a meta-analysis

Zhang, Dong; Yao, Lifeng; Yu, Sui; Cheng, Yue; Jiang, Junhui; Ma, Qi; Yan, Zejun

doi:10.1186/s12957-019-1776-4

Table 1 Characteristics of included studies

From: Safety and efficacy of en bloc transurethral resection versus conventional transurethral resection for primary nonmuscle-invasive bladder cancer: a meta-analysis

Study	Study design	LOE	Surgical method	Tumor size		No. of patients	Grade			T-stage			P/M/E/BCG	NOS score
				EBRT	CTURBT	EBRT CTURBT		EBRT	CTURBT		EBRT	CTURBT
Zhu et al. 2008	Retrospective	3b	Holmium laser/CTURBT	≤ 3 cm 95 > 3 cm 6	104 7	101/111	1 2 3	36 54 9	38 63 10	Ta T1	67 34	70 41	M	*******
Zhong1 et al. 2010	Retrospective	3b	2-micron laser/CTURBT	2.23	1.54	30/42	LMP LG HG	4 21 5	7 26 9	Ta T1 Cis	23 5 2	30 8 4	E	*******
Zhong2 et al. 2010	Retrospective	3b	Holmium laser/CTURBT	1.38	1.54	25/42	LMP LG HG	3 18 4	7 26 9	Ta T1 Cis	19 5 1	30 8 4	E	*******
Liu et al. 2013	RCT	2b	2-micron laser/MCTURBT	1.31	1.28	64/56	LMP LG HG	11 46 7	10 41 5	Ta T1	37 27	34 22	E	–
Sureka et al. 2015	Prospective	2b	EBRT/MCTURBT	2.8	3.3	21/24	NM	NM	NM	Ta T1	12 9	13 11	BCG	*******
Chen et al. 2015	RCT	2b	2-micron laser/CTURBT	2.6	2.3	71/71	LMP LG HG	5 43 23	9 45 17	Ta T1 Cis	43 25 3	55 15 1	E	–
Xu et al. 2015	RCT	2b	2-micron laser/MCTURBT	≤ 3 cm 81 > 3 cm 18	≤ 3 cm 79 > 3 cm 15	116/113	1 2 3	50 39 10	48 41 5	Ta T1	91 8	82 12	P	–
Zhang et al. 2015	RCT	2b	2-micron laser/BCTURBT	≤ 3 cm 98 > 5 cm 51	≤ 3 cm 95 > 5 cm 48	149/143	G0 G1 G2	87 54 8	75 60 8	Ta T1	10 6 43	107 36	E	–
Cheng et al. 2017	Retrospective	3b	KTP laser/CTURBT	1.65	1.5	34/30	Low High	19 2	20 0	Ta T1	14 16	13 15	M	*******
Zhang et al. 2017	Retrospective	3b	EBRT/MCTURBT	≤ 3 cm 32 > 3 cm 8	≤ 3 cm 38 > 3 cm 12	40/50	LMP LG HG	9 22 9	12 23 15	Ta T1	15 25	27 23	P	******
Balan et al. 2018	Prospective	2b	EBRT/MCTURBT	1.82	1.69	45/45	NM	NM	NM	Ta T1	24 21	23 22	E and BCG	******
Li et al. 2018	Retrospective	3b	TH laser/CTURBT	2.39	2.15	136/120	NM	NM	NM	NM	NM	NM	P	*******
Yang et al. 2013	Retrospective	3b	KTP laser/CTURBT	≤ 3 cm 24 > 3 cm 4	≤ 3 cm 26 > 3 cm 6	28/32	1 2 3	15 10 3	16 10 6	Ta T1	8 20	7 25	E	******
Tao et al. 2013	Retrospective	3b	KTP laser/CTURBT	2.1	1.9	74/84	LMP LG HG	9 60 5	10 68 6	Ta T1 Cis	50 23 1	61 21 2	E	******
Cheng et al. 2018	Retrospective	3b	HybridKnife/CTURBT	2.5	2.8	95/98	LMP LG HG	5 48 40	8 37 48	Ta T1	52 43	54 44	P	*******
D’souza et al. 2016	Retrospective	3b	Holmium laser/MCTURBT	1.41	1.58	27/23	LMP LG HG	5 20 2	4 16 3	Ta T1	16 11	15 8	M	*******
Song et al. 2010	Retrospective	3b	Holmium laser/MCTURBT	1.85	1.74	64/51	LMP LG HG	5 39 20	4 33 14	Ta T1 Cis	36 23 5	30 17 4	M	*******
Huang1 et al. 2016	Retrospective	3b	2-micron laser/MCTURBT	1.63	1.53	70/70	LMP LG HG	20 40 10	18 46 6	Ta T1 Cis	40 23 7	35 27 8	E	********
Huang2 et al. 2016	Retrospective	3b	Holmium laser/MCTURBT	1.58	1.53	70/70	LMP LG HG	15 48 7	18 46 6	Ta T1 Cis	37 28 5	35 27 8	E	********
Xu et al. 2017	Retrospective	3b	Holmium laser/CTURBT	2.3	2.2	26/44	LMP LG HG	4 14 8	3 28 13	Ta T1	10 12	25 16	P	*******
Chen et al. 2016	Prospective	2b	Green laser/CTURBT	1.85	1.71	83/75	LMP LG HG	12 61 10	8 55 12	Ta T1	70 13	64 11	M	*******

RCT randomized control trial, NM not mention, CTURBT conventional transurethral resection of bladder tumor, MCTURBT monopolar conventional transurethral resection of bladder tumor, BCTURBT bipolar conventional transurethral resection of bladder tumor, EBRT en bloc resection of bladder tumor, LMP low malignant potential, LG low grade, HG high grade, P pirarubicin, M mitomycin, E epirubicin, BCG Bacille Calmette-Guerin

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